Results 71 to 80 of about 8,123,417 (252)
Russian Migration Policy and Its Impact on Human Development [PDF]
For Russia, migration policy – in terms of internal or/and international migration flows management – was an ever-important element of the State activities. Concentrated on State interests, the policy also resulted in human development.
Ivakhnyuk, Irina
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
The Impact of Demographic Change on Human Capital Accumulation [PDF]
This paper investigates whether and to what extent demographic change has an impact on human capital accumulation. The effect of the relative cohort size on educational attainment of young adults in Germany is analyzed utilizing data from the German ...
Christoph M. Schmidt +2 more
core +3 more sources
A decade of study on the condition of western Cuban coral reefs, with low human impact. [PDF]
PeerJ, 2023 Caballero-Aragón H +5 more
europepmc +1 more source
ILR Impact Brief - Affective Commitment Links Human Resource Practices and Voluntary Turnover [PDF]
, 2008 [Excerpt] Motivation- and empowerment- enhancing human resource (HR) practices are positively associated with employees’ collective emotional attachment to, and identification with, a company and its goals; this affective commitment, in turn, is ...
Gardner, Timothy +2 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Valuing Human Impact of Natural Disasters: A Review of Methods. [PDF]
Int J Environ Res Public Health, 2022 Kharb A +5 more
europepmc +1 more source
The human impact of heatwaves and extreme weather [PDF]
In the last century, Australia\u27s average temperature rose by slightly less than one degree over the pre-industrial average. Without concerted action by all countries, including Australia, the world is on a path to exceeding 4°C by the 2060s ...
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source