Results 91 to 100 of about 535,803 (298)

Differential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses [PDF]

, 2006
In 1997, avian influenza virus H5N1 was transmitted directly from chicken to human and resulted in a severe disease that had a higher mortality rate in adults than in children.
Cheung, CY, Lau, YL, Law, HKW, Ng, IHY, Peiris, JSM, Zhou, J   +5 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Randomized, double-blind, multi-center, phase III clinical trial to evaluate the immunogenicity and safety of MG1109 (egg-based pre-pandemic influenza A/H5N1 vaccine) in healthy adults

Human Vaccines & Immunotherapeutics, 2017
Considering the pandemic potential of avian influenza A/H5N1, development of an effective and well-tolerated vaccine is an essential part of pandemic preparedness plans.
Joon Young Song, Min Joo Choi, Ji Yun Noh, Won Suk Choi, Hee Jin Cheong, Seong-Heon Wie, Jin-Soo Lee, Gyu-Jin Woo, Sang Ho Lee, Woo Joo Kim   +9 more
doaj   +1 more source

First sequence-confirmed case of infection with the new influenza A(H1N1) strain in Germany [PDF]

, 2009
Here, we report on the first sequence-confirmed case of infection with the new influenza A(H1N1) virus in Germany. Two direct contacts of the patient were laboratory-confirmed as cases and demonstrate a chain of direct human-to-human ...
Feierabend, K., Jilg, W., Kochanowski, B., Kreuzpaintner, B., Kreuzpaintner, E., Melzl, H., Niller, H. H., Reischl, U., Rohrhofer, A., Salzberger, B., Schreder-Meindl, S., Wenzel, J. J., Wolf, H., Wollner, H.   +13 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Polarity of influenza H5N1 virus infection in respiratory epithelial cells and the impact of basolateral release of cytokines in disease pathogenesis [PDF]

, 2008
Poster Presentations: Virus Host Interaction/PathogenesisINTRODUCTION: Highly pathogenic avian influenza virus (H5N1) is the first avian influenza virus that documented to cause respiratory disease and death in human.
Chan, MCW, Chan, RWY, Chui, WH, Guan, Y, Nicholls, JM, Peiris, JSM, Yu, CL   +6 more
core  

Host adaptation and transmission of influenza A viruses in mammals [PDF]

, 2014
A wide range of influenza A viruses of pigs and birds have infected humans in the last decade, sometimes with severe clinical consequences. Each of these so-called zoonotic infections provides an opportunity for virus adaptation to the new host ...
Fouchier, R.A.M. (Ron), Schrauwen, E.J.A. (Eefje)   +1 more
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

No serological evidence that harbour porpoises are additional hosts of influenza B viruses [PDF]

, 2014
Influenza A and B viruses circulate among humans causing epidemics almost annually. While various hosts for influenza A viruses exist, influenza B viruses have been detected only in humans and seals.
Bildt, M.W.G. (Marco) van de, Bodewes, R. (Rogier), Bunskoek, P.E. (Paulien), Elk, C.E. (Niels) van, Kuiken, T. (Thijs), Osterhaus, A.D.M.E. (Albert), Smits, S.L. (Saskia), Vijver, D.A.M.C. (David) van de   +7 more
core   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source