Results 131 to 140 of about 595,560 (387)

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints‟ involvement and serum inflammatory markers (raised serum C-reactive protein & erythrocyte ...
Sardar Muhammad, Amer Fakhr, Muhammad Adnan Manzar, Farzana Hakim, Taimoor Ashraf Khan, Bilal Ahmad   +5 more
doaj  

The human leukocyte antigen and genetic susceptibility in human diseases

Journal of Bio-X Research, 2019
. The human leukocyte antigen (HLA) complex is involved in immunity, belongs to a highly polymorphic family of genes, and is found in a disease-associated region of the human genome.
Jinping Gao, Caihong Zhu, Zhengwei Zhu, Lili Tang, Lu Liu, Leilei Wen, Liangdan Sun   +6 more
doaj   +1 more source

Clinical intestinal transplantation: New perspectives and immunologic considerations [PDF]

, 1998
Background: Although tacrolimus-based immunosuppression has made intestinal transplantation feasible, the risk of the requisite chronic high- dose treatment has inhibited the widespread use of these procedures.
Abu-Elmagd, K, Bueno, J, Demetris, J, Fawzy, AT, Fung, JJ, Furukawa, H, Irish, W, Lee, R, McMichael, J, Murase, N, Rakela, J, Rao, A, Reyes, J, Starzl, TE, Todo, S   +14 more
core   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Human leukocyte antigen associations in postural tachycardia syndrome

Annals of Clinical and Translational Neurology, 2019
Associations between human leukocyte antigen (HLA) and postural orthostatic tachycardia syndrome (POTS) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign ...
Yong‐Won Shin, Jangsup Moon, Tae‐Joon Kim, Do‐Yong Kim, Hyeyeon Chang, Jin‐Sun Jun, Soon‐Tae Lee, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Manho Kim, Sang Kun Lee, Kon Chu   +12 more
doaj   +1 more source

Using high-resolution human leukocyte antigen typing of 11,423 randomized unrelated individuals to determine allelic varieties, deduce probable human leukocyte antigen haplotypes, and observe linkage disequilibria between human leukocyte antigen-B and-C and human leukocyte antigen-DRB1 and-DQB1 alleles in the Taiwanese Chinese population

Tzu Chi Medical Journal, 2017
Objective: We report here the human leukocyte antigen (HLA) allelic variety and haplotype composition in a cohort of the Taiwanese Chinese population and their patterns of linkage disequilibria on HLA-B: HLA-C alleles and HLA-DRB1: HLA-DQB1 alleles at a ...
Kuo-Liang Yang, Hsee-Bin Chen
doaj   +1 more source

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Studies with human leukocyte lysosomes. Evidence for antilysosome antibodies in lupus erythematosus and for the presence of lysosomal antigen in inflammatory diseases. [PDF]

, 1975
David Bell, Patricia A. Thiem, J H Vaughan, J P Leddy   +3 more
openalex   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source