Analysis of the role of leukocyte function-associated antigen-1 in activation of human influenza virus-specific T cell clones. [PDF]
, 1990 K C Kuijpers +5 more
openalex +1 more source
Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors.
European Journal of Cancer, 2019 Omar Hasan Ali +10 more
semanticscholar +1 more source
Generative Humanization for Therapeutic Antibodies [PDF]
arXivAntibody therapies have been employed to address some of today's most challenging diseases, but must meet many criteria during drug development before reaching a patient. Humanization is a sequence optimization strategy that addresses one critical risk called immunogenicity - a patient's immune response to the drug - by making an antibody more "human ...
arxiv
Antigen targeting to dendritic cells: Still a place in future immunotherapy?
European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022 Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner +4 more
wiley +1 more source
IL‐4/IL‐13‐producing ILC2s are required for timely control of intestinal helminth infection in mice
European Journal of Immunology, Volume 52, Issue 12, Page 1925-1933, December 2022., 2022 ILC2‐derived IL‐4/IL‐13 plays a non‐redundant role for eosinophil recruitment to the lung and expulsion of N. brasiliensis worm parasites from the intestine. Abstract Infection of mice with Nippostrongylus brasiliensis (Nb) serves as a model for human hookworm infection affecting about 600 million people world‐wide.
Filipa Varela +4 more
wiley +1 more source
Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene. [PDF]
, 1990 Michael J. Chorney +5 more
openalex +1 more source
TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah +2 more
wiley +1 more source
Recent advances and challenges in temperature monitoring and control in microfluidic devices
ELECTROPHORESIS, Volume 44, Issue 1-2, Page 268-297, January 2023., 2023 Abstract Temperature is a critical—yet sometimes overlooked—parameter in microfluidics. Microfluidic devices can experience heating inside their channels during operation due to underlying physicochemical phenomena occurring therein. Such heating, whether required or not, must be monitored to ensure adequate device operation.
Alejandro A. Dos‐Reis‐Delgado +6 more
wiley +1 more source
Family Studies and Human Leukocyte Antigen Class II Typing in Indian Probands with Seizures in Association with Single Small Enhancing Computed Tomography Lesions [PDF]
, 1999 Sanjeev Jain +5 more
openalex +1 more source