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Human leukocyte antigens in tuberculosis and leprosy
Trends in Microbiology, 1998Human mycobacterial infections are characterized by a spectrum of clinical and immunological manifestations. Specific human leukocyte antigen (HLA) factors are associated with the subtypes of leprosy that develop and the course of tuberculosis after infection.
Klaus Stark +2 more
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Human leukocyte antigens and drug hypersensitivity
Current Opinion in Allergy & Clinical Immunology, 2007The present article reviews the recent literature on the identification of human leukocyte antigen (HLA) alleles as major susceptible genes for drug hypersensitivity and discusses the clinical implications.Several recent studies have reported strong genetic associations between HLA alleles and susceptibility to drug hypersensitivity.
Yuan-Tsong Chen +2 more
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Human leukocyte antigen epitope antigenicity and immunogenicity
Current Opinion in Organ Transplantation, 2014Human leukocyte antigen (HLA) antibodies are now recognized as being specific for epitopes which can be defined structurally with amino acid differences between HLA alleles. This article addresses two general perspectives of HLA epitopes namely antigenicity, that is their reactivity with antibody and immunogenicity, that is their ability of eliciting ...
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Human leukocyte antigens and Gaucher disease
Blood Cells, Molecules, and Diseases, 2013Gaucher disease (GD) is caused by the reduced activity of lysosomal enzyme glucocerebrosidase, which leads to the accumulation of glucocerebroside in macrophages and a chronic stimulation of the immune system. GD is divided into 3 main types according to the presence or absence of neurological involvement and to its presentation (acute or chronic ...
Filippo Vairo +8 more
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Human Leukocyte Antigens in Undifferentiated Spondyloarthritis
Seminars in Arthritis and Rheumatism, 2007Undifferentiated spondyloarthritis (USpA) is a major member of the spondyloarthritis family. Ankylosing spondylitis (AS), the prototype of the family, is a largely genetic disease, with human leukocyte antigens (HLA)-B27 being the essential gene. Other genes in the HLA region have also been implicated.
Chun Hsiung Chen +10 more
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Characterization of human leukocyte differentiation antigens
Immunology Today, 1987What would impel 190 different laboratories to work together in the performance of more than 150 000 assays to characterize about 800 antibodies? Participants in the 3rd International Workshop on Human Leukocyte Differentiation Antigens generally shared the conviction that such cooperative effort has the potential to bring order out of the chaos of ...
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Human Leukocyte Antigens in Bell's Palsy
Annals of Otology, Rhinology & Laryngology, 1988Ninety-three patients with Bell's palsy including 12 members of two families with familial Bell's palsy were typed for human leukocyte antigens (HLAs). Significant association between HLAs and Bell's palsy was found. The association of certain HLAs with the palsy may predict the specific clinical course and prognosis.
Hiroshi Okamura +2 more
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Becoming a chef in the human leukocyte antigen kitchen
Current Opinion in Organ Transplantation, 2017Fluorescence-based human leukocyte antigen (HLA) antibody detection methods, including flow cytometric crossmatch and single antigen bead assays revolutionized HLA antibody identification and assessment of immunological risk in transplant candidates and patients. Nevertheless, these assays are not flawless and their interpretation can be complex.
Robert S. Liwski +3 more
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The human leukocyte antigens and their relationship to infection
The American Journal of Surgery, 1993Human leukocyte antigen DR (HLA-DR) expression on peripheral blood monocytes has been found to correlate highly with infection in many clinical scenarios. This is particularly true for the trauma patient, where changes in HLA-DR expression predate and therefore often predict development of infection.
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Surface Antigens of Human Leukocytes
1991Publisher Summary The aim of this chapter is to provide a comprehensive overview of the well-characterized surface molecules of human leukocytes. It is useful to have a brief compilation of this field as a whole that would enable one to quickly find at least the basic information on both the well-known and less familiar molecules and provide a ...
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