Structural modification of clofoctol yielded a novel blood‐brain barrier‐permeable compound, B7, featuring a multi‐substituted diaryl scaffold. B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion ...
Yong‐jian Wang+9 more
wiley +1 more source
Human Leukocyte Antigen (HLA) at the Root of Persistent Antigens and Long COVID. [PDF]
Georgopoulos AP, James LM, Peterson PK.
europepmc +1 more source
CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade
This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou+15 more
wiley +1 more source
Circulating donor-specific cytotoxic T lymphocytes with high avidity for donor human leukocyte antigens in pediatric and adult cardiac allograft valved conduit recipients✩ [PDF]
Frans B S Oei+6 more
openalex +1 more source
Assessment of Functional Status of Human Leukocyte Antigen Class I Genes in Cancer Tissues in the Context of Personalized Neoantigen Peptide Vaccine Immunotherapy. [PDF]
Padul VG+6 more
europepmc +1 more source
Human Leukocyte Antigen Type and Posttransplant Lymphoproliferative Disorder
M. Lustberg+7 more
semanticscholar +1 more source
Conditional Survival for Pancreas Graft and Its Associated Factors After Pancreas Transplantation
This study investigates conditional survival (CS) for pancreas grafts in recipients of pancreas transplantation (PTx) in Japan, using data from 526 cases. Findings reveal that CS increases over time post‐transplant, offering a more optimistic long‐term prognosis than traditional actuarial survival. While donor sex and PTx procedure type influence early
Yoshito Tomimaru+5 more
wiley +1 more source
Allele-Selective Genome Editing of the Human Leukocyte Antigen Locus in Human Dental Pulp Cells Using Zinc Finger Nucleases. [PDF]
Kuroda I+8 more
europepmc +1 more source
Chimerism after whole organ transplantation: an explanation of renal and other organ acceptance [PDF]
Demetris, AJ+5 more
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