Results 301 to 310 of about 595,560 (387)
Population-level toggling of T cell immune escape at human leukocyte antigen anchor residues in SARS-CoV-2 Spike proteins, in an ethnically diverse population region. [PDF]
Ngandu NK+5 more
europepmc +1 more source
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun+19 more
wiley +1 more source
New Associations with the HIV Predisposing and Protective Alleles of the Human Leukocyte Antigen System in a Peruvian Population. [PDF]
Obispo D+7 more
europepmc +1 more source
Eligibility for Human Leukocyte Antigen-Based Therapeutics by Race and Ethnicity.
Olivier T, Haslam A, Tuia J, Prasad V.
europepmc +1 more source
Objectives The effect of the shared epitope (SE), and valine at position 11 (Val11) of HLA‐DRB1, on the activation of CD4+ T cells, is expected to be diminished by abatacept, a co‐stimulation blocker. However, published evidence on the value of genetic stratification for abatacept treatment is conflicting.
Chuan Fu Yap+14 more
wiley +1 more source
A Rare Case of Ketosis-Prone Type 2 Diabetes With a Unique Human Leukocyte Antigen (HLA) Profile: Genetic and Metabolic Insights. [PDF]
Mukai M+4 more
europepmc +1 more source
Objective Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet+18 more
wiley +1 more source