Results 61 to 70 of about 8,336,904 (303)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Human leukocyte antigen-A*24:02-B*40:247-C*03:04-DRB1*16:02, a deduced probable human leukocyte antigen haplotype associated with a low-incidence human leukocyte antigen allele B*40:247 in Taiwanese individuals: A case analysis

Tzu Chi Medical Journal, 2018
Objective: HLA-B*40:247 is a low incidence allele in the HLA-B locus. The aim of this study is to confirm the ethnicity of B*40:247 and its deduced probable HLA- associated haplotype in Taiwanese individuals.
Kuo-Liang Yang, Zheng-Zhong Zheng, Li-Yun Lin   +2 more
doaj   +1 more source

Study design showing the relationship between human leukocyte antigen genes, islet autoantibodies, C-peptide and diabetic retinopathy.

, 2013
Study design showing the relationship between human leukocyte antigen genes, islet autoantibodies, C-peptide and diabetic retinopathy.
Carina Törn (354789), Åke Lernmark (2577040), Nicholas L. Smith (354787), David S. Siscovick (174822), Richard A. Jensen (103656), Elisabet Agardh (93248), Soffia Gudbjörnsdottir (5652148)   +6 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Allele and haplotype frequencies of human platelet and leukocyte antigens in platelet donors

Einstein (São Paulo)
Objective To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood.
Valeria de Freitas Dutra, Carolina Bonet Bub, Thiago Henrique Costa, Leandro Dinalli Santos, Eduardo Peres Bastos, Maria Giselda Aravechia, José Mauro Kutner   +6 more
doaj   +1 more source

Observed and expected heterozygosity and Hardy–Weinbergsignificance for human leukocyte antigen-A, -B, and -DRB1loci in Tujia ethnicity.

, 2013
Observed and expected heterozygosity and Hardy–Weinbergsignificance for human leukocyte antigen-A, -B, and -DRB1loci in Tujia ethnicity.
Yulin Yuan (319370), Dangxiao Cheng (319368), Min Zhao (66793), Xiaoping Qiu (319372), Li Zhang (8200), Ning Tao (109880), Fan Zhang (46132)   +6 more
core   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints‟ involvement and serum inflammatory markers (raised serum C-reactive protein & erythrocyte ...
Sardar Muhammad, Amer Fakhr, Muhammad Adnan Manzar, Farzana Hakim, Taimoor Ashraf Khan, Bilal Ahmad   +5 more
doaj   +4 more sources

Deduced probable human leukocyte antigen haplotypes associated with human leukocyte antigen DRB1*04:36 identified by case analysis of Taiwanese individuals

Tzu Chi Medical Journal, 2017
Objective: Human leukocyte antigen (HLA) DRB1*04:36 is a low-frequency HLA-DRB1 allele. The aim here is to report the ethnicity of DRB1*04:36 and its associated HLA haplotypes among Taiwanese individuals.
Kuo-Liang Yang, Zheng-Zhong Zheng
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source