Results 71 to 80 of about 359,068 (363)

Human leukocyte antigen variation and Parkinson’s disease [PDF]

Parkinsonism & Related Disorders, 2011
A role for the immune system in the pathogenesis of Parkinson's Disease (PD) has previously been suggested. A recent genome-wide association (GWA) study identified an association between one single nucleotide polymorphism (SNP) in the human leucocyte antigen (HLA) region (HLA-DRA rs3129882) and PD in a population of American patients with European ...
Michael G. Heckman, Maria Barcikowska, Anna Krygowska-Wajs, Andreas Puschmann, Andreas Puschmann, Barbara Jasinska-Myga, Alexandra I. Soto-Ortolaza, Owen A. Ross, Zbigniew K. Wszolek, Grzegorz Opala, Ryan J. Uitti, Christophe Verbeeck, Timothy Lynch, Timothy Lynch   +13 more
openaire   +5 more sources

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Immune Shielding of Human Heart Valves:A Proof-of-Concept Study of HLA-Targeting Therapy for Transplantations [PDF]

Children born with defective heart valves require multiple donor valve replacements throughout life, because these cannot grow and can cause early failure through immune degeneration. This study tests the lentiviral delivery of viral immune evasion genes
Bouten, Carlijn V.C., Goumans, Marie Jose, Groeneveld, Esmee J., Hoeben, Rob C., Peerlings, Janneke H., Peters, Marijn C., Rabelink, Martijn J.W.E., van den Bogaerdt, Antoon, van Wijk, Abraham, Zaldumbide, Arnaud   +9 more
core   +1 more source

Assessment of the genetic basis of rosacea by genome-wide association study. [PDF]

, 2015
Rosacea is a common, chronic skin disease that is currently incurable. Although environmental factors influence rosacea, the genetic basis of rosacea is not established.
Chang, Anne Lynn S, Chen, Julia, Eriksson, Nicholas K, Hinds, David A, Kiefer, Amy K, Li, Rui, Raber, Inbar, Spitale, Robert, Tian, Chao, Tung, Joyce Y, Xu, Jin   +10 more
core   +1 more source

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses [PDF]

, 2015
Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies.
arxiv   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

HLA Class I and Class II Polymorphisms and Anti-nuclear Antibodies in Hyperprolactinaemic Iraqi Females with Primary Infertility

مجلة كلية الطب, 2009
Background: The study was conducted to investigate the association between hyperprolactinaemia and markers of human leukocyte antigen (HLA) system in a sample of Iraqi infertile females, together with the profile anti-nuclear antibodies (ANA ...
Ali H. Ad'hiah, Manal B. Al-Tmemi, Sabah M. Hussain, Nahi Y. yaseen   +3 more
doaj   +1 more source

Human Leukocyte Antigen-DR is a Differentiation Antigen for Human Granulosa Cells1 [PDF]

Biology of Reproduction, 1993
We raised a murine monoclonal antibody, OG-3, which reacts with human granulosa cells. Immunohistologically, OG-3 antigen was weakly expressed on the granulosa cells of some growing and atretic follicles, but not on those of preovulatory follicles.
Hiroshi Fujiwara, Masamichi Ueda, Kimitoshi Imai, Masatsune Fukuoka, Keiko Yasuda, Kenji Takakura, Hiroshi Suginami, Hideharu Kanzaki, Hidetoshi Inoko, Takahide Mori, Michiyuki Maeda   +10 more
openaire   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source