Results 71 to 80 of about 400,125 (363)

Detection of CD33 expression on monocyte surface is influenced by phagocytosis and temperature [PDF]

, 2019
CD33 is a myeloid-associated marker and belongs to the sialic acid-binding immunoglobulin (Ig)-like lectin (Siglec) family. Such types of receptors are highly expressed in acute myeloid leukemia, which could be used in its treatment.
Baisaeng, Nuttakorn, Boonla, Chanchai, Bäumler, Hans, Georgieva, Radostina, Kaewprayoon, Waraporn, Kloypan, Chiraphat, Smuda, Kathrin, Suwannasom, Nittiya   +7 more
core   +1 more source

Human leukocyte antigen variation and Parkinson’s disease [PDF]

Parkinsonism & Related Disorders, 2011
A role for the immune system in the pathogenesis of Parkinson's Disease (PD) has previously been suggested. A recent genome-wide association (GWA) study identified an association between one single nucleotide polymorphism (SNP) in the human leucocyte antigen (HLA) region (HLA-DRA rs3129882) and PD in a population of American patients with European ...
Michael G. Heckman, Maria Barcikowska, Anna Krygowska-Wajs, Andreas Puschmann, Andreas Puschmann, Barbara Jasinska-Myga, Alexandra I. Soto-Ortolaza, Owen A. Ross, Zbigniew K. Wszolek, Grzegorz Opala, Ryan J. Uitti, Christophe Verbeeck, Timothy Lynch, Timothy Lynch   +13 more
openaire   +5 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

HLA Class I and Class II Polymorphisms and Anti-nuclear Antibodies in Hyperprolactinaemic Iraqi Females with Primary Infertility

مجلة كلية الطب, 2009
Background: The study was conducted to investigate the association between hyperprolactinaemia and markers of human leukocyte antigen (HLA) system in a sample of Iraqi infertile females, together with the profile anti-nuclear antibodies (ANA ...
Ali H. Ad'hiah, Manal B. Al-Tmemi, Sabah M. Hussain, Nahi Y. yaseen   +3 more
doaj   +1 more source

Human Leukocyte Antigen-DR is a Differentiation Antigen for Human Granulosa Cells1 [PDF]

Biology of Reproduction, 1993
We raised a murine monoclonal antibody, OG-3, which reacts with human granulosa cells. Immunohistologically, OG-3 antigen was weakly expressed on the granulosa cells of some growing and atretic follicles, but not on those of preovulatory follicles.
Hiroshi Fujiwara, Masamichi Ueda, Kimitoshi Imai, Masatsune Fukuoka, Keiko Yasuda, Kenji Takakura, Hiroshi Suginami, Hideharu Kanzaki, Hidetoshi Inoko, Takahide Mori, Michiyuki Maeda   +10 more
openaire   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The MHC locus and genetic susceptibility to autoimmune and infectious diseases

Genome Biology, 2017
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases.
Vasiliki Matzaraki, Vinod Kumar, Cisca Wijmenga, Alexandra Zhernakova   +3 more
doaj   +1 more source

Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells. [PDF]

, 1983
We have examined the morphology, cytochemistry, and biochemistry of mouse leukocyte subsets by analyzing cloned leukocyte populations specialized to perform different immunologic functions.
Cantor, H, der Simonian, H, Dvorak, AM, Dvorak, HF, Galli, SJ, Goldin, J, Marcum, JA, Monahan, RA, Nabel, G, Pyne, K, Rosenberg, RD   +10 more
core  

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

Human leukocyte antigen - HLA B*27: Unraveling the link to pathogenesis

Indian Journal of Rheumatology, 2020
The association of spondyloarthritis (SpA) with human leukocyte antigen-B*27 (HLA-B*27) is one of the strongest known for a non-monogenic disease.
Sakir Ahmed, Ramnath Misra
doaj   +1 more source