Results 81 to 90 of about 348,506 (362)

Human Leukocyte Antigens and Malignant Essential Hypertension [PDF]

American Journal of Hypertension, 1998
The purpose of this study was to investigate an association between human leukocyte antigens (HLA) and the susceptibility to malignant hypertension. The presence of HLA-A, -B, -DR, and -DQ was determined in 33 white and in 23 mulatto Brazilian patients with malignant essential hypertension. No statistically significant differences were detected between
Gerbase-DeLima, M., Paiva, RLF, Bortolotto, L. A., Bernardes-Silva, H., De Lima, JJG   +4 more
openaire   +4 more sources

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions [PDF]

arXiv, 2023
Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have attracted considerable interest for predicting specific interactions between antibody candidates and target antigens such as viruses and bacteria.
arxiv  

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

Neonatal alloimmune thrombocytopenia caused by anti-HPA antibodies in pregnant Chinese women: a study protocol for a multicentre, prospective cohort trial

BMC Pregnancy and Childbirth, 2017
Background Neonatal alloimmune thrombocytopenia (NAIT), caused by maternal antibodies raised against alloantigens carried on foetal platelets, is a very common haematological abnormality in newborns worldwide.
Li Chen, Zhiwei Liu, Tiemei Liu, Xianjun Ma, Meiying Rao, Yongjun Wang, Bo Sun, Wen Yin, Jun Zhang, Beizhan Yan, Xiaojuan Li, Qiushi Wang, Lei Zhang, Jun Wen, Fenghua Liu, Peng Wang, Yaming Wei, Yuanshuai Huang, Jiang Wu, Yi Guo, Yinlan Kang, Xiaochuan Song, Xiangfu Liu, Genling Zhang, Tingting Xie, Yonggeng Chen, Xiaojing Zeng, Zhongjun Li   +27 more
doaj   +1 more source

Sarcopenia and Variation in the Human Leukocyte Antigen Complex [PDF]

The Journals of Gerontology: Series A, 2019
Abstract Background Aging is characterized by chronic inflammation plus loss of muscle mass and strength, termed sarcopenia. Human leukocyte antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance.
David Melzer, David Melzer, George A. Kuchel, Luigi Ferrucci, Luke C. Pilling, Garan Jones, Chia-Ling Kuo   +6 more
openaire   +4 more sources

Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient‐derived xenograft models

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma patient‐derived xenografts (PDAC‐PDXs) engrafted orthotopically in the pancreas of immunodeficient mice retain the main genetic and histopathological characteristics of the original human tumors. A 294 stroma gene signature differentiates between PDAC‐PDXs that are responsive to gemcitabine plus nab‐paclitaxel versus ...
Alessia Anastasia, Laura Formenti, Paola Ostano, Lucia Minoli, Andrea Resovi, Lavinia Morosi, Claudia Fioravanti, Edoardo Micotti, Cristina Matteo, Eugenio Scanziani, Giovanna Chiorino, Raffaella Giavazzi, Carmen Ghilardi, Dorina Belotti   +13 more
wiley   +1 more source

HLA class I binding prediction via convolutional neural networks [PDF]

arXiv, 2017
Many biological processes are governed by protein-ligand interactions. One such example is the recognition of self and nonself cells by the immune system. This immune response process is regulated by the major histocompatibility complex (MHC) protein which is encoded by the human leukocyte antigen (HLA) complex.
arxiv  

Assessment of the genetic basis of rosacea by genome-wide association study. [PDF]

, 2015
Rosacea is a common, chronic skin disease that is currently incurable. Although environmental factors influence rosacea, the genetic basis of rosacea is not established.
Chang, Anne Lynn S, Chen, Julia, Eriksson, Nicholas K, Hinds, David A, Kiefer, Amy K, Li, Rui, Raber, Inbar, Spitale, Robert, Tian, Chao, Tung, Joyce Y, Xu, Jin   +10 more
core   +1 more source

The MHC locus and genetic susceptibility to autoimmune and infectious diseases

Genome Biology, 2017
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases.
Vasiliki Matzaraki, Vinod Kumar, Cisca Wijmenga, Alexandra Zhernakova   +3 more
doaj   +1 more source