Results 131 to 140 of about 22,575,443 (355)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Metaphysics of Human Life. Towards a New Reading of Spinoza’s Philosophy

Journal of Spinoza Studies, 2022
Ursula Renz
doaj   +1 more source

The Immunological Epigenetic Landscape of the Human Life Trajectory. [PDF]

Biomedicines, 2022
Juříčková I, Hudec M, Votava F, Vosáhlo J, Ovsepian SV, Černá M, O'Leary VB.   +6 more
europepmc   +1 more source

Understanding Human Life

, 2022
How to try to understand human life is the challenge addressed by this book, which compares our life experience with the attempts to grasp it by astrologers, eugenicists, psychologists, neuroscientists, social scientists, and philosophers. The main opposition in the previous list lies between understanding and misunderstanding, and the difficulty to ...
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Genetic strategies for sex-biased persistence of gut microbes across human life. [PDF]

Nat Commun, 2023
Tarracchini C, Alessandri G, Fontana F, Rizzo SM, Lugli GA, Bianchi MG, Mancabelli L, Longhi G, Argentini C, Vergna LM, Anzalone R, Viappiani A, Turroni F, Taurino G, Chiu M, Arboleya S, Gueimonde M, Bussolati O, van Sinderen D, Milani C, Ventura M.   +20 more
europepmc   +1 more source

The Chronotope of Humanness : Bakhtin and Dostoevsky [PDF]

, 2010
Bakhtin and Dostoevsky shared the conviction that human life must be understood in terms of temporality. Both thinkers were obsessed with time’s relation to life as people experience it.
Morson, Gary Saul
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A high-dimensional cytometry atlas of peripheral blood over the human life span. [PDF]

Immunol Cell Biol, 2022
Jalali S, Harpur CM, Piers AT, Auladell M, Perriman L, Li S, An K, Anderson J, Berzins SP, Licciardi PV, Ashhurst TM, Konstantinov IE, Pellicci DG.   +12 more
europepmc   +1 more source

The "life code": a theory that unifies the human life cycle and the origin of human tumors.

Seminars in Cancer Biology, 2020
Jinsong Liu
semanticscholar   +1 more source