Results 131 to 140 of about 23,652,053 (356)

The optimal accumulation of human capital over the life cycle / BEBR No.553 [PDF]

Includes bibliographical references (p. 28)."This paper summarizes the important contributions of the new life cycle human capital literature and demonstrates that many of these results can be derived more simply than in their original presentations ...
Graham, John W.
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The Immunological Epigenetic Landscape of the Human Life Trajectory. [PDF]

Biomedicines, 2022
Juříčková I, Hudec M, Votava F, Vosáhlo J, Ovsepian SV, Černá M, O'Leary VB.   +6 more
europepmc   +1 more source

Understanding Human Life

, 2022
How to try to understand human life is the challenge addressed by this book, which compares our life experience with the attempts to grasp it by astrologers, eugenicists, psychologists, neuroscientists, social scientists, and philosophers. The main opposition in the previous list lies between understanding and misunderstanding, and the difficulty to ...
openaire   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Genetic strategies for sex-biased persistence of gut microbes across human life. [PDF]

Nat Commun, 2023
Tarracchini C, Alessandri G, Fontana F, Rizzo SM, Lugli GA, Bianchi MG, Mancabelli L, Longhi G, Argentini C, Vergna LM, Anzalone R, Viappiani A, Turroni F, Taurino G, Chiu M, Arboleya S, Gueimonde M, Bussolati O, van Sinderen D, Milani C, Ventura M.   +20 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A high-dimensional cytometry atlas of peripheral blood over the human life span. [PDF]

Immunol Cell Biol, 2022
Jalali S, Harpur CM, Piers AT, Auladell M, Perriman L, Li S, An K, Anderson J, Berzins SP, Licciardi PV, Ashhurst TM, Konstantinov IE, Pellicci DG.   +12 more
europepmc   +1 more source

HUMOR IN JALAN PINGGIR CRITICISM COLUMN IN SILATURAHIM RUBRIC SUARA MUHAMMADIYAH MAGAZINE (A PRAGMATIC STUDY) [PDF]

, 2011
In human life, human beings will not be separated from problems, any time man strives to get trough the problem, ranging from minor problems in life, to the tragedy that changed someone’s life, this thesis tells about a character named Andrew Laeddis is ...
HANDAYANI, NITA DIAN
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source