Results 151 to 160 of about 8,915,710 (312)

The human life vs economic loss dilemma: Relation between death rate and the output rate in Europe during the Covid 19 pandemic. [PDF]

J Policy Model, 2023
Bollino CA.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modeling study. [PDF]

Elife, 2022
Yang B, García-Carreras B, Lessler J, Read JM, Zhu H, Metcalf CJE, Hay JA, Kwok KO, Shen R, Jiang CQ, Guan Y, Riley S, Cummings DA.   +12 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases. [PDF]

Int J Mol Sci, 2021
Youssef M, Ahmed HY, Zongo A, Korin A, Zhan F, Hady E, Umair M, Shahid Riaz Rajoka M, Xiong Y, Li B.   +9 more
europepmc   +1 more source

Long-Run Trends of Human Aging and Longevity [PDF]

Over the last 200 years humans experienced a huge increase of life expectancy. These advances were largely driven by extrinsic improvements of their environment (for example, the available diet, disease prevalence, vaccination, and the state of hygiene ...
Holger Strulik, Sebastian Vollmer
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The effective connectome over a century of human life. [PDF]

Commun Biol
Li G, Huynh KM, Thung KH, Taylor Iv HP, Lin G, Lin W, Ahmad S, Yap PT.   +7 more
europepmc   +1 more source

Functional connectome through the human life span

, 2023
Sun L, Zhao T, Liang X, Xia M, Li Q, Liao X, Gong G, Wang Q, Pang C, Yu Q, Bi Y, Chen P, Chen R, Chen Y, Chen T, Cheng J, Cheng Y, Cui Z, Dai Z, Deng Y, Ding Y, Dong Q, Duan D, Gao J, Gong Q, Han Y, Han Z, Huang C, Huang R, Huo R, Li L, Lin C, Lin Q, Liu B, Liu C, Liu N, Liu Y, Liu Y, Lu J, Ma L, Men W, Qin S, Qiu J, Qiu S, Si T, Tan S, Tang Y, Tao S, Wang D, Wang F, Wang J, Wang P, Wang X, Wang Y, Wei D, Wu Y, Xie P, Xu X, Xu Y, Xu Z, Yang L, Yuan H, Zeng Z, Zhang H, Zhang X, Zhao G, Zheng Y, Zhong S, Alzheimer’s Disease Neuroimaging Initiative, Cam-CAN, Developing Human Connectome Project, DIDA-MDD Working Group, MCADI, NSPN, He Y.   +74 more
europepmc   +1 more source