Results 141 to 150 of about 22,575,443 (355)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation. [PDF]
Sci Adv, 2023 Treaster S +5 more
europepmc +1 more source
A Religious Pacifist Looks at Abortion [PDF]
, 1971 From the standpoint of the religious pacifist, Professor Zahn sees elementary human rights beginning at the moment of conception marking the beginning of the individual\u27s life process, and argues against abortion from this ...
Zahn, Gordon C.
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Protecting and Promoting the Human Right to Respect for Family Life: Treaty-Based Reform and Domestic Advocacy [PDF]
, 2010 This article examines the right to respect for family life in international law, focusing on its underlying principles and explicit protections. The article identifies these legal norms so that drafters of international treaties, specifically the ...
Mrazik, Ryan, Schoenholtz, Andrew I.
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Human Capabilities and Human Authorities: A Comment on Martha Nussbaum’s Women and Human Development [PDF]
, 2003 What does it mean to be truly human? And, relatedly, what does it mean to be treated as truly human, and with dignity, by the state, or community, of which one is a part?
West, Robin
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Role of Estradiol Hormone in Human Life and Electrochemical Aptasensing of 17β-Estradiol: A Review. [PDF]
Biosensors (Basel), 2022 Waifalkar PP +4 more
europepmc +1 more source
Angels, beasts, machines, and men: Configuring the human and nonhuman in Judaeo-Christian tradition [PDF]
, 2008 This is the author's pdf version of the book chapter.This book chapter offers four snapshots from the Judaeo-Christian tradition of the theological significance of the distinction between human and nonhuman ...
Clough, David
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