Results 161 to 170 of about 8,857,203 (292)

Life-Cyle Fertility Behavior and Human Capital Accumulation [PDF]

This paper develops and implements a semiparametric estimator for investigating, with panel data, the importance of human capital accumulation, non-separable preferences of females and child care costs on females life-cycle fertility and labor supply ...
George-Levi Gayle, Robert Miller
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modeling study. [PDF]

Elife, 2022
Yang B, García-Carreras B, Lessler J, Read JM, Zhu H, Metcalf CJE, Hay JA, Kwok KO, Shen R, Jiang CQ, Guan Y, Riley S, Cummings DA.   +12 more
europepmc   +1 more source

Human Capital Inequality, Life Expectancy and Economic Growth [PDF]

This paper provides a theoretical model in which inequality affects per capita income when individuals decide to accumulate human capital depending on their life expectancy.
Climent, Amparo Castello, Rafael Domenech   +1 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases. [PDF]

Int J Mol Sci, 2021
Youssef M, Ahmed HY, Zongo A, Korin A, Zhan F, Hady E, Umair M, Shahid Riaz Rajoka M, Xiong Y, Li B.   +9 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Functional connectome through the human life span

, 2023
Sun L, Zhao T, Liang X, Xia M, Li Q, Liao X, Gong G, Wang Q, Pang C, Yu Q, Bi Y, Chen P, Chen R, Chen Y, Chen T, Cheng J, Cheng Y, Cui Z, Dai Z, Deng Y, Ding Y, Dong Q, Duan D, Gao J, Gong Q, Han Y, Han Z, Huang C, Huang R, Huo R, Li L, Lin C, Lin Q, Liu B, Liu C, Liu N, Liu Y, Liu Y, Lu J, Ma L, Men W, Qin S, Qiu J, Qiu S, Si T, Tan S, Tang Y, Tao S, Wang D, Wang F, Wang J, Wang P, Wang X, Wang Y, Wei D, Wu Y, Xie P, Xu X, Xu Y, Xu Z, Yang L, Yuan H, Zeng Z, Zhang H, Zhang X, Zhao G, Zheng Y, Zhong S, Alzheimer’s Disease Neuroimaging Initiative, Cam-CAN, Developing Human Connectome Project, DIDA-MDD Working Group, MCADI, NSPN, He Y.   +74 more
europepmc   +1 more source

Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life. [PDF]

Cytokine, 2021
Smolen KK, Plotkin AL, Shannon CP, Idoko OT, Pak J, Darboe A, van Haren S, Amenyogbe N, Tebbutt SJ, Kollmann TR, Kampmann B, Ozonoff A, Levy O, Odumade OA, EPIC Consortium.   +14 more
europepmc   +1 more source