Results 221 to 230 of about 131,492 (236)

How Does the Kenosis Fit into the Incarnation? [PDF]

, 2017
Willmington, Harold
core   +1 more source

In- vitro assessment of the anti- malarial potential of Alpha Onocerin; cytotoxicity and hemolytic effect, multi-stage activity and molecular docking. [PDF]

BMC Pharmacol Toxicol
Appiah JA, Tetteh J, Zoiku F, Amoatey AO, Osei KJ, Agyemang Antwi S, Addotey JN, Ansah C, Mensah KB.   +8 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

AI-driven <i>de novo</i> design of BRAF inhibitors with enhanced binding affinity and optimized drug-likeness. [PDF]

PeerJ
Lu Z, Zhang A.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Multi-omics analysis: Gut microbial metabolites in ovarian lesions. [PDF]

J Int Med Res
Yinghong L, Xiaojuan Y, Xiaojuan Y.
europepmc   +1 more source

Design and Antischizophrenic Studies of 1,3-disubstituted Chalcone Derivatives: <i>In-silico</i> Molecular Docking Approach. [PDF]

Trop Life Sci Res
Zubair AO, Danladi S, Ibrahim UI, Jibril MK, Ilyasu S.   +4 more
europepmc   +1 more source

The potential mechanism and immunomodulatory effect of gut microbiota-derived metabolites in the treatment of gastric cancer by integrating network pharmacology and molecular docking. [PDF]

Clin Exp Med
Chen Y, Wang R, Wang S, Xia Z, Wang J, Wang B.   +5 more
europepmc   +1 more source