Characterization of 3-Hydroxyeticyclidine (3-HO-PCE) Metabolism in Human Liver Microsomes and Biological Samples Using High-Resolution Mass Spectrometry. [PDF]
Metabolites, 2023 Larabi IA +3 more
europepmc +1 more source
Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1584-1596, June 2026.Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub +5 more
wiley +1 more source
Development and Validation of a Rapid LC-MS/MS Method for Quantifying Alvocidib: In Silico and In Vitro Metabolic Stability Estimation in Human Liver Microsomes. [PDF]
Molecules, 2023 Attwa MW, AlRabiah H, Kadi AA.
europepmc +1 more source
eFood, Volume 7, Issue 3, June 2026.Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy +7 more
wiley +1 more source
Herb-drug interaction of Astragali Radix based on in vitro incubation and pharmacokinetic assessment
BMC Complementary Medicine and TherapiesBackground Astragali Radix (AR) is extensively utilized in Asia for its various pharmacological effects. With the widespread use of AR, the risk of herb-drug interactions (HDIs) mediated by cytochrome P450 (P450) enzymes has become a serious concern ...
Tianwang Wang +6 more
doaj +1 more source
When Cofactors Aren't X Factors: Functional Groups That Are Labile in Human Liver Microsomes in the Absence of NADPH. [PDF]
ACS Med Chem Lett, 2022 Landry ML +3 more
europepmc +1 more source
, 1979 The effects of naturally occurring microsomal enzyme inducers on important hepatocellular pathways for the metabolism of foreign compounds (xenobiotics) and also upon the incidence of liver tumours in CF-1 mice treated or not with 10 mg dieldrin.kg ...
Tennekes, H.A.
core
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Achillea millefolium Linn., commonly known as yarrow, is an extraordinary medicinal plant. A. millefolium has broad therapeutic potential due to its phytochemistry and essential oil composition. It possesses pharmacological properties, including antidiabetic, antioxidant, anti‐inflammatory, liver‐protective, antimicrobial, and gastroprotective effects,
Tooba Majeed +14 more
wiley +1 more source
Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes. [PDF]
Metabolites, 2022 Crosby SV +9 more
europepmc +1 more source
Reproxalap ‐ A Novel Treatment Option for Allergic Conjunctivitis – A Comprehensive Narrative Review
Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims Allergic conjunctivitis is a prevalent, immune‐mediated hypersensitivity disorder of the ocular surface affecting 10%–20% of the global population. Current therapeutic options, while effective to some extent, are often limited by side effects and inconsistent efficacy.
Sanila Mughal +7 more
wiley +1 more source