Results 151 to 160 of about 27,101 (273)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Evaluation of Liver Damage and Herbal Detoxification of Coral Reef Fish Caused by Ammonia Stress

Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
Slybum marianum can reduce ammonia stress and enhance liver protection in marine fish. ABSTRACT Ammonia nitrogen can cause serious toxicological damage to fish and cause fish death. This study focused on liver damage caused by ammonia nitrogen stress in coral reef fish and used herbal extracts to improve ammonia poisoning and prevent liver tissue ...
Wei‐Ting Sun, You‐Ren Lai, De‐Sing Ding, Chih‐Hung Pan   +3 more
wiley   +1 more source

Characterization of furathiocarb metabolism in in-vitro human liver microsomes and recombinant cytochrome P450 enzymes. [PDF]

Toxicol Rep, 2022
Abass K, Reponen P, Alsanie WF, Rautio A, Pelkonen O.   +4 more
europepmc   +1 more source

Guanethidine N-oxidation in human liver microsomes

, 1987
The capacity of human liver microsomes to N-oxidize guanethidine from 25 subjects has been assessed. Guanethidine N-oxidation was optimal at pH 8ṁ5 and proceeded at only 16% of the maximal rate at pH 7ṁ4.
P H Grantham, P J Wirth, D S Davies, A R Boobis, M E McManus   +4 more
core   +1 more source

Transcriptomic Analysis in the Liver of Two Rabbit Lines Divergently Selected for Intramuscular Fat Content

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines ...
Jesús Valdés‐Hernández, Agostina Zubiri‐Gaitán, Marina Martínez‐Álvaro, Agustín Blasco, Pilar Hernández   +4 more
wiley   +1 more source

Identification and cross-species comparison of in vitro phase I brevetoxin (BTX-2) metabolites in northern Gulf of Mexico fish and human liver microsomes by UHPLC-HRMS(/MS). [PDF]

Toxicon X, 2023
Gwinn JK, Robertson A, Ivanova L, Fæste CK, Kryuchkov F, Uhlig S.   +5 more
europepmc   +1 more source

Glucuronidation of diflunisal in liver and kidney microsomes of rat and man.

, 1996
1. The glucuronidation of diflunisal to its phenolic (DPG) and acyl glucuronide (DAG) was measured in vitro using microsomes prepared from rat (n = 4) and human (n = 6) liver and kidney tissue.
Brunelle, F M, Verbeeck, Roger-K.
core   +1 more source

Structure–Activity Relationship Study on Ligands Activating the Voltage‐Gated Potassium Channel KV7.1

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Activation of the voltage gated K+ channel KV7.1 leads to hyperpolarization shift of cell membranes. In a thorough SAR study eight positions of the lead compound (R)‐L3 were modified. (R)‐configuration, the indolylmethyl moiety in 3‐position and the 2‐fluorophenyl moiety in 5‐position appeared to be essential for high KV7.1 activation, whereas an OH ...
Florian Roßner, Judith Schmidt, Guiscard Seebohm, Bernhard Wünsch   +3 more
wiley   +1 more source

Targeted Metabolomics of Organophosphate Pesticides and Chemical Warfare Nerve Agent Simulants Using High- and Low-Dose Exposure in Human Liver Microsomes. [PDF]

Metabolites, 2023
Agarwal G, Tichenor H, Roo S, Lane TR, Ekins S, McElroy CA.   +5 more
europepmc   +1 more source

Isoniazid‐Related Secondary Drug‐Induced Autoimmune Hepatitis in a Patient Diagnosed With Ankylosing Spondylitis and Tuberculous Lymphadenitis: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Autoimmune hepatitis is a type of chronic hepatitis that is usually progressive, has unknown etiology, and can occur at any age. In the present case, drug‐associated autoimmune hepatitis (DIAIH) was discussed, and DIAIH secondary to isoniazid (INH) was found in two case reports in the literature.
Murat AY, Erhan Bozkurt
wiley   +1 more source