Results 131 to 140 of about 50,120 (254)

Eicosapentaenoic and Docosahexaenoic Acid Levels in Mouse Tissues After Intake of Echium and Ahiflower Oils Rich in Stearidonic and α‐Linolenic Acids

Lipids, Volume 61, Issue 3, Page 417-426, May 2026.
Dietary supplementation with stearidonic acid–rich Echium and Ahiflower oils increases EPA levels across multiple mouse tissues, while DHA responses remain tissue‐specific and limited, supporting the strategic use of plant‐based omega‐3 sources for EPA‐focused interventions. ABSTRACT Omega‐3 fatty acids (n‐3 FA), particularly eicosapentaenoic acid (EPA)
Letícia V. Segre, Mariana S. Bisinotto, Inar A. Castro   +2 more
wiley   +1 more source

Impact of metabolic enzyme activity variability on dabrafenib disposition

Frontiers in Pharmacology
IntroductionThe systemic exposure of dabrafenib correlates with its adverse drug reactions. A thorough understanding of its pharmacokinetic profile is crucial for precise clinical application.MethodsAn optimized liver microsomal incubation system was ...
Shi-yu Wang, Shi-yu Wang, Qing Chen, Zhong-xi Chen, Jing Chen, Jing Yuan, Li-shang Dai, Lian-guo Chen, Xiao-dan Zhang, Xiao-dan Zhang   +9 more
doaj   +1 more source

Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes. [PDF]

Molecules, 2022
Su S, Wu H, Zhou J, Yuan G, Wang H, Feng J.   +5 more
europepmc   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method. [PDF]

Molecules, 2023
Attwa MW, AlRabiah H, Mostafa GAE, Bakheit AH, Kadi AA.   +4 more
europepmc   +1 more source

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Manuela G. Neuman, Paul A. Hwang, Radu M. Nanau   +3 more
core   +1 more source

AlphaFold‐driven discovery of oxysterol‐binding protein‐related protein‐phosphoinositide 3‐, 4‐, and 5‐phosphatase interactions using new generation confidence scores

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Non‐vesicular lipid transport contributes to the regulation of membrane composition and organelle function at membrane contact sites. OSBP‐related proteins (ORPs) are central to this process, yet their interaction networks remain incompletely defined. Here, we systematically screened potential interactions between ORPs and phosphoinositide 3‐,
Filippo Dall'Armellina, Sylvie Urbé, Daniel J. Rigden   +2 more
wiley   +1 more source

Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann, Constanze C. Schmies, Georg Wilhelm Rolshoven, Mirko Scortichini, Stefan Wagner, Andreas Isaak, Riham M. Idris, Jennifer Dabel, Lucie Grey, Karolina Losenkova, Susanne Moschütz, Haneen Al Hroub, Antje Keim, Sandra Höppner, Jouko Sandholm, Pia Boström, Maija Hollmén, Norbert Sträter, Sven Hermann, Gennady G. Yegutkin, Kenneth A. Jacobson, Sonja Schelhaas, Christa E. Müller, Anna Junker   +23 more
wiley   +2 more sources

Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation. [PDF]

Molecules, 2023
Attwa MW, AlRabiah H, Mostafa GAE, Kadi AA.   +3 more
europepmc   +1 more source

Machine Learning Meets Pharmacokinetics: A Comparative Analysis of Predictive Models for Plasma Concentration‐Time Profiles

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Predicting pharmacokinetic (PK) profiles from molecular structures represents a significant advancement in pharmaceutical research with substantial implications for expediting drug discovery processes. We evaluated five approaches to systematically compare five distinct methodological frameworks for predicting rat plasma concentration‐time ...
Felix Jost, Clemens Giegerich, Christoph Grebner, Hans Matter, Henrik Cordes   +4 more
wiley   +1 more source