Results 111 to 120 of about 23,100 (164)
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In Vitro Metabolism of Flucetosulfuron by Human Liver Microsomes
Journal of Agricultural and Food Chemistry, 2014To investigate herbicide metabolism, human liver microsomes were incubated with threo- and erythro-isomers of flucetosulfuron. Each isomer produced one metabolite; the metabolites were unambiguously identified as enzymatic hydrolysis products by using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Kwang-Hyeon Liu +2 more
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Enantioselective Metabolism of Flufiprole in Rat and Human Liver Microsomes
Journal of Agricultural and Food Chemistry, 2016The enantioselective metabolism of flufiprole in rat and human liver microsomes in vitro was investigated in this study. The separation and determination were performed using a liquid chromatography system equipped with a triple-quadrupole mass spectrometer and a Lux Cellulose-2 chiral column.
Mingrong Qian, Hu Zhang, Chunmian Lin
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The lipid composition of human liver microsomes
Lipids, 1982AbstractThe lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid ...
L, Waskell, D, Koblin, E, Canova-Davis
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Microsomal Esterification of Retinol in Human Liver
Acta Medica Scandinavica, 1984Abstract Recent work has shown that esterification of retinol in microsomes from rat liver, mammary gland and small intestine and from human small intestine is catalyzed by an acyl CoA: retinol acyl transferase (ARAT). The current study demonstrates ARAT activity in human liver microsomes.
M, Rasmussen +3 more
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The metabolism of tramadol by human liver microsomes
The Clinical Investigator, 1992The metabolism of tramadol was investigated in vitro using microsomal fractions of human liver. The parent compound and its main metabolites were determined by a newly developed high performance liquid chromatography assay. O-demethylation of tramadol was found to be stereoselective. The Vmax of the O-demethylation of (-)-tramadol was 210 pmol.mg-1.min-
W D, Paar, P, Frankus, H J, Dengler
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REDUCTION OF 3-OXOSTEROIDS IN HUMAN LIVER MICROSOMES
Acta Endocrinologica, 1976ABSTRACT The 3α- and 3β-reduction of the following steroids was studied in human liver microsomes: 5α-androstane-3,17-dione, 17β-hydroxy-5α-androstan-3-one, 5α-pregnane-3,20-dione, 5β-pregnane-3,20-dione, 3-oxo-5β-cholanoic acid and 7α-hydroxy-5α-cholestan-3-one.
I, Björkhem +3 more
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Characterization of metronidazole metabolism by human liver microsomes
Biochemical Pharmacology, 1991The metabolism of metronidazole was studied in microsomes isolated from livers of human kidney donors. The formation of the major in vivo metabolite, hydroxymetronidazole, proceeded according to biphasic kinetics, suggesting the involvement of at least two enzymatic sites.
S, Loft +4 more
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Variation in glucuronidation of lamotrigine in human liver microsomes
Xenobiotica, 2009Lamotrigine (LTG), a diaminotriazine anti-epileptic, is principally metabolized at the 2-position of the triazine ring to form a quaternary ammonium glucuronide (LTGG) by uridine glucuronosyl transferease (UGT) 1A3 and UGT1A4. It has been hypothesized that glucuronidation of anti-epileptic drugs is spared with age, despite a known decrease in liver ...
U A, Argikar, R P, Remmel
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Metabolism of Ketamine Stereoisomers by Human Liver Microsomes
Anesthesiology, 1992Ketamine is used clinically as a racemic mixture of optical isomers that differ in their analgesic properties and psychomimetic effects. Administered individually, or together as the racemate, ketamine enantiomers differ in their hepatic clearance and duration of anesthetic effect.
E D, Kharasch, R, Labroo
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