Results 101 to 110 of about 27,101 (273)

Characterization Of In Vitro Metabolism of Brucine Using Human Liver Microsomes

, 2010
Background. Brucine, one of the bitter alkaloids isolated from Chinese folk medicine Strychnos nux-vomica L. (Loganiaceae), is known as an effective analgesic and anti- inflammatory agent for relieving arthritic and traumatic pain.
房中则, 葛广波, Ling Yang, 杨凌, 毛玉玺   +4 more
core  

Determination of UDP-glucuronosyltransferase UGT2B7 activity in human liver microsomes by ultra-performance liquid chromatography with MS detection

, 2008
A rapid and specific ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) method was developed for the qualitative and quantitative determination of UGT2B7 activity using 3'-azido-3'-deoxythymidine (AZT) as probe substrate in human ...
Hu, Ying, He, Yu-Qi, Zhang, Jiang-Wei, Liu, Hui-Xin, Li, Wei, 杨凌, Liu, Yong, Wang, Zheng-Tao, Yang, Ling   +8 more
core   +1 more source

Drug-related problems and dosage adjustment in patients with liver disease [PDF]

, 2012
The liver is essential for the metabolism of medicinal substances. Liver disease, especially liver cirrhosis, may lead to various pharmacokinetic and pharmacodynamic changes, predisposing patients with liver cirrhosis to adverse drug events (ADEs).
Franz, Carmen Carina
core   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Pig, Monkey and Human

, 2010
Cinobufagin (CBG), a major bioactive component of Traditional Chinese Medicine ChanSu with digoxin-like structure, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成, 葛广波, 宁静, 杨凌, 马骁驰   +4 more
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Inhibition constants of EGCG on cortisone reduction with human liver microsomes and purified human 11β-HSD1.

, 2014
Inhibition constants of EGCG on cortisone reduction with human liver microsomes and purified human 11β-HSD1.
Edmund Maser (258257), Claudia Stapelfeld (505745), Christine Loerz (505746), Hans-Joerg Martin (258253), Jan Hintzpeter (505744)   +4 more
core   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Comparative Metabolism of Cinobuafgin in Liver Microsomes from Mouse,Rat,Dog,Pig,Monkey and Human

, 2010
Cinobufagin (CBG), a major bioactive component of Traditional Chinese Medicine Chan-Su with digoxin-like structure, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成, 葛广波, 宁静, 杨凌, 马骁驰   +4 more
core  

Metabolism of [3-14C] coumarin by human liver microsomes

, 1994
1. The metabolism of 50 mu M [3-C-14] coumarin has been studied in a panel of 12 human liver microsomal samples of known P450 isoenzyme profile.2. [3-C-14] coumarin was metabolized by human liver microsomes to various polar products including 3-, 4- and ...
van Iersel, M.L.P.S., Price, R. J., Walters, D. G., van Iersel, M. L. P. S., Henderson, C. J., Henderson, C.J., Wolf, C. R., Lake, B.G., Lake, B. G., Price, R.J., Iersel, M.L.P.S., van, Walters, D.G., Wolf, C.R.   +12 more
core   +1 more source

In vitro and in vivo metabolism profiles of cathinone and pseudoephedrine: Discrimination between khat and pseudoephedrine uses

Journal of Forensic Sciences, EarlyView.
Abstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Jong Suk Park, Jun Sang Yu, Yejin Kim, Hee Seung Kim, Jae Chul Cheong, Jin Young Kim, Hye Hyun Yoo   +6 more
wiley   +1 more source