Results 91 to 100 of about 50,120 (254)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Metabolic Stability and Metabolite Characterization of Capilliposide B and Capilliposide C by LC–QTRAP–MS/MS

Pharmaceutics, 2018
Capilliposide B (LC-B) and Capilliposide C (LC-C), two new triterpenoid saponins extracted from Lysimachia capillipes Hemsl, exhibit potential anticancer activity both in vitro and in vivo. However, their metabolic process remains unclear. In this study,
Zhongzhe Cheng, Xing Zhou, Zhifeng Du, Wenyi Li, Bingying Hu, Jingkui Tian, Lin Zhang, Jiangeng Huang, Hongliang Jiang   +8 more
doaj   +1 more source

DNA adducts in fish following an oil spill exposure [PDF]

, 2006
On 12 December 1999, one third of the load of the Erika tanker, amounting to about 10,000 t crude oil flowed into sea waters close to the French Atlantic Coast.
A. Amat, A. Pfohl-Leszkowicz, B French, B Kurelec, B Kurelec, BP Lyons, BP Lyons, C Genevois, CA Rice, D Petrapiana, DH Phillips, DH Phillips, E Aas, E Randerath, EJ Stein, F Telli-Karakok, F Vincent, FJ Van Schooten, G Ericson, G Ericson, G Ericson, JS Harvey, K Boillot, L Mazeas, LD Peters, M. Castegnaro, MC Poirier, MM Bradford, MS Myers, PAEL Schilderman, PC Baumann, R Amara, RA Lyons, T Burgeot, T. Burgeot, U Varanasi, WL Reichert   +36 more
core   +3 more sources

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites

Toxicology Reports, 2015
Qualitative trapping profile of reactive metabolites arising from six structurally different compounds was tested with three different d-peptide isomers (Peptide 1, gly–tyr–pro–cys–pro–his-pro; Peptide 2, gly–tyr–pro–ala–pro–his–pro; Peptide 3, gly–tyr ...
Jaana E. Laine, Merja R. Häkkinen, Seppo Auriola, Risto O. Juvonen, Markku Pasanen   +4 more
doaj   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [PDF]

, 2006
Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation.
Bourges-Abella, Nathalie, Cadot, R., Gallissot, Frédéric, Lambert, A.M., Morel, G., Sabaté, Jean-Philippe, Saillenfait, Anne-Marie   +6 more
core   +1 more source

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

Systematic Characterization of In Vitro and In Vivo Metabolic Pathways and Identification of Novel Biomarkers of 26 Synthetic Cannabinoids

Molecules
In recent years, the harms and abuse of synthetic cannabinoids (SCs) have attracted extensive attention in society. Their structures have been updated rapidly, which brings great challenges for continuous detection and drug identification.
Yudie Ning, Tao Wang, Xiao Yang, Fang Guo, Yingwen Xu, Yuan Zhang, Kaile Wang, Meng Hu, Zhe Chen, Zhiwen Wei, Keming Yun   +10 more
doaj   +1 more source

Inhibition of cytochrome P450 enzymes by thymoquinone in human liver microsomes

Saudi Pharmaceutical Journal, 2018
The aim of the present study was to investigate the potential effect of thymoquinone (TQ) on the metabolic activity of four major drug metabolizing enzymes in human liver microsomes, namely cytochrome P450 (CYP) 1A2, CYP2C9, CYP2D6 and CYP3A4.
Ahmed A. Albassam, Abdul Ahad, Abdullah Alsultan, Fahad I. Al-Jenoobi   +3 more
doaj   +1 more source