Results 91 to 100 of about 27,101 (273)

Systematic Characterization of In Vitro and In Vivo Metabolic Pathways and Identification of Novel Biomarkers of 26 Synthetic Cannabinoids

Molecules
In recent years, the harms and abuse of synthetic cannabinoids (SCs) have attracted extensive attention in society. Their structures have been updated rapidly, which brings great challenges for continuous detection and drug identification.
Yudie Ning, Tao Wang, Xiao Yang, Fang Guo, Yingwen Xu, Yuan Zhang, Kaile Wang, Meng Hu, Zhe Chen, Zhiwen Wei, Keming Yun   +10 more
doaj   +1 more source

Human liver microsomal oxidation of .DELTA.8-tetrahydrocannabinol.

Chemical and Pharmaceutical Bulletin, 1983
Human Liver microsomal oxidation products of Δ8-tetrahydrocannabinol (THC) were isolated and identified by thin-layer chromatography, gas chromatography and gas chromatography-mass spectrometry. As the results, five monohydroxylated metabolites including 11-hydroxy-Δ8-THC, and 8β, 9α-dihydroxyhexahydrocannabinol were identified as trimethyl-silyl ...
Yamamoto, Ikuo, Narimatsu, Shizuo, Watanabe, Kazuhito, Shimonishi, Tatsuyuki, Yoshimura, Hidetoshi, Nagano, Taizo   +5 more
openaire   +3 more sources

Characterization of in vitro bioactivation of rutaecarpine in human liver microsomes (HLMs)

, 2010
Reactive drug metabolites have been always considered mediators of drug-induced toxicities and risk would increase with the increasing reactive metabolites.
房中则, Ling Yang, 杨凌
core  

Theophylline Metabolism by Human, Rabbit and Rat Liver Microsomes and by Purified Forms of Cytochrome P450

, 1988
The capacity of human, rabbit and rat liver microsomes and purified isozymes of cytochrome P450 to metabolize theophylline has been assessed. In all three species the 8-hydroxylation of theophylline to 1,3-dimethyluric acid (1,3-DMU) was the major ...
J O Miners, I Stupans, D Gregor, M E McManus, D J Birkett   +4 more
core   +1 more source

In vitro metabolism of 20(R)-25-methoxyl-dammarane-3, 12, 20-triol from Panax notoginseng in human, monkey, dog, rat, and mouse liver microsomes.

PLoS ONE, 2014
The present study characterized in vitro metabolites of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(R)-25-OCH3-PPD) in mouse, rat, dog, monkey and human liver microsomes.
Xiangrong Zhang, Ji Zhang, Wei Li, Li Liu, Baoshan Sun, Zhenghong Guo, Caihong Shi, Yuqing Zhao   +7 more
doaj   +1 more source

In Vitro Metabolic Study of Boc5 in human tissues and Animal Liver Microsomes

, 2009
As the first nonpeptidic agonist of glucagon-like peptide 1 receptor, Boc5 can invoke sustained glycemic control and weight loss in diabetic C57BL/6J mice, and has become a promising hit compound for antidiabetic drug. Boc5 displays good efficiency via i.
梁思成, 葛广波, Ling Yang, 刘勇, 杨凌   +4 more
core  

Metabolic stability in human liver microsomes.

, 2015
BG-323 was incubated with pooled human liver microsomes. After reaction initiation with NADPH, reactions were sampled at times 0, 10, 30 and 60 minutes. BG-323 concentrations were determined by LC-MS/MS at each time point (n = 1).
Susan M. Keenan (755174), Elnaz Soltani (755173), J. Jordan Steel (499663), Brian J. Geiss (342132), Kristen M. Bullard (755171), Rebekah C. Gullberg (755172)   +5 more
core   +1 more source

Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes

, 2018
The roles of human cytochrome P450 (P450 or CYP) 2A6 in the oxidation of flavanone [(2R)- and (2S)-enantiomers] and flavone were studied in human liver microsomes and recombinant human P450 enzymes.CYP2A6 was highly active in oxidizing flavanone to form ...
Masayuki Komori (1655731), Tsutomu Shimada (1655737), F. Peter Guengerich (272072), Donghak Kim (1337931), Haruna Nagayoshi (1527844), Young-Ran Lim (2740963), Kensaku Kakimoto (1527838), Vitchan Kim (4803177), Hiroshi Yamazaki (78272), Jun Katahira (30963), Norie Murayama (220718), Shigeo Takenaka (1655734)   +11 more
core   +1 more source

Bovine liver slices combined with an androgen transcriptional activation assay: an in-vitro model to study the metabolism and bioactivity of steroids [PDF]

, 2010
Previously we described the properties of a rapid and robust yeast androgen bioassay for detection of androgenic anabolic compounds, validated it, and showed its added value for several practical applications.
S. Van Kuijk, Kuijk, S., J. H. Riethoff-Poortman, Rijk, J.C.W., T. F. H. Bovee, Wang, S., Peijnenburg, A.A.C.M., Poortman, J.H., Bovee, T.F.H., S. Wang, J. C. W. Rijk, A. A. C. M. Peijnenburg   +11 more
core   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source