Results 241 to 250 of about 27,101 (273)

Effect of benzodiazepines on the metabolism of buprenorphine in human liver microsomes

European Journal of Clinical Pharmacology, 2005
To determine whether enzyme inhibition explains the clinical adverse interaction of benzodiazepines and buprenorphine.Buprenorphine was incubated in the presence of benzodiazepines (or metabolites) with human liver microsomes (HLMs). A number of benzodiazepines were screened at therapeutic concentrations after 0-min and 15-min preincubation times.
Yan, Chang, David E, Moody
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Aminopyrine N-demethylase activity in human liver microsomes

Clinical Pharmacology and Therapeutics, 1990
Aminopyrine N-demethylase activity and the contents of cytochrome P-450, cytochrome b5, and NADPH-reductase activity in human liver microsomes from 31 different patients were studied. Our results show the existence of significant interindividual, but not sex- or age-related differences in N-demethylase activity (ranging between 0.52 and 4.42 nmol/min ...
J A, García-Agúndez, A, Luengo, J, Benítez   +2 more
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In Silico Modeling of Nonspecific Binding to Human Liver Microsomes

Drug Metabolism and Disposition, 2008
Estimation of unbound fraction of substrate in microsomal incubation media is important in accurately predicting hepatic intrinsic clearance and drug-drug interactions. In this study, the unbound fraction of 1223 drug-like molecules in human liver microsomal incubation media has been determined using equilibrium dialysis. These compounds, which include
Hua, Gao, Lili, Yao, Heather W, Mathieu, Ying, Zhang, Tristan S, Maurer, Matthew D, Troutman, Dennis O, Scott, Roger B, Ruggeri, Jing, Lin   +8 more
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Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4

Clinical Pharmacology and Therapeutics, 1989
The metabolism of lidocaine to its major metabolite monoethylglycinexylidide (MEGX) was studied in human liver microsomes of 13 kidney transplant donors and of one patient with liver cirrhosis. Interindividual variation in metabolite formation was considerable.
Bargetzi MJ, Aoyama T, Gonzalez FJ, Meyer UA   +3 more
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Role of human liver microsomal CYP2C9 in the biotransformation of lornoxicam

European Journal of Clinical Pharmacology, 1996
The nature of the enzyme(s) catalysing the biotransformation of lornoxicam to one of its major metabolites, 5'-hydroxy-lornoxicam, has been investigated in human liver microsomes. The reaction kinetics were characterised, the affinity of lornoxicam for three major human drug metabolising cytochrome P-450 isozymes (CYP2C9, CYP2D6 and CYP3A4) was ...
Bonnabry P, Leemann T, Dayer P
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Flavin-Containing Monooxygenase Activity in Human Liver Microsomes

1986
Human liver microsomal flavin-containing monooxygenase activity has been studied using dimethylaniline N-oxidation and thiobenzamide S-oxidation. Except for one subject, the capacity of human liver microsomes to mediate these reactions were markedly increased at pH 8.4 compared to pH 7.4.
M E, McManus, D J, Birkett, W M, Burgess, I, Stupans, J A, Koenig, A R, Boobis, D S, Davies, P J, Wirth, P H, Grantham, S S, Thorgeirsson   +9 more
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Human liver microsomal drug metabolism

Biochemical Pharmacology, 1970
F J, Darby, W, Newnes, D A, Price Evans
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Metabolism of phencyclidine by human liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals, 1997
These studies examined in vitro metabolism of phencyclidine (PCP) in a series of human liver microsomes (N = 10). Each sample was characterized for cytochrome P450 (CYP) content and for CYP1A, CYP2A, CYP2C, CYP2D, CYP2E, CYP3A, CYP4A, and lauric acid 11-hydroxylation metabolic activities.
E M, Laurenzana, S M, Owens
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INDUCTION OF THE UNSPECIFIC MICROSOMAL HYDROXYLASE IN THE HUMAN LIVER

Drug Metabolism and Disposition, 1973
H, Remmer, B, Schoene, R A, Fleischmann
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OXIDATIVE DRUG METABOLISM IN HUMAN LIVER MICROSOMES

The Journal of Pharmacology and Experimental Therapeutics, 1971
E B, Nelson, P P, Raj, K J, Belfi, B S, Masters   +3 more
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