Results 221 to 230 of about 27,101 (273)

Enantioselective Metabolism of Flufiprole in Rat and Human Liver Microsomes

Journal of Agricultural and Food Chemistry, 2016
The enantioselective metabolism of flufiprole in rat and human liver microsomes in vitro was investigated in this study. The separation and determination were performed using a liquid chromatography system equipped with a triple-quadrupole mass spectrometer and a Lux Cellulose-2 chiral column.
Chunmian, Lin, Yelong, Miao, Mingrong, Qian, Qiang, Wang, Hu, Zhang   +4 more
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The lipid composition of human liver microsomes

Lipids, 1982
AbstractThe lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid ...
L, Waskell, D, Koblin, E, Canova-Davis
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Microsomal Esterification of Retinol in Human Liver

Acta Medica Scandinavica, 1984
Abstract Recent work has shown that esterification of retinol in microsomes from rat liver, mammary gland and small intestine and from human small intestine is catalyzed by an acyl CoA: retinol acyl transferase (ARAT). The current study demonstrates ARAT activity in human liver microsomes.
M, Rasmussen, P, Helgerud, L B, Petersen, K R, Norum   +3 more
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The metabolism of tramadol by human liver microsomes

The Clinical Investigator, 1992
The metabolism of tramadol was investigated in vitro using microsomal fractions of human liver. The parent compound and its main metabolites were determined by a newly developed high performance liquid chromatography assay. O-demethylation of tramadol was found to be stereoselective. The Vmax of the O-demethylation of (-)-tramadol was 210 pmol.mg-1.min-
W D, Paar, P, Frankus, H J, Dengler
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REDUCTION OF 3-OXOSTEROIDS IN HUMAN LIVER MICROSOMES

Acta Endocrinologica, 1976
ABSTRACT The 3α- and 3β-reduction of the following steroids was studied in human liver microsomes: 5α-androstane-3,17-dione, 17β-hydroxy-5α-androstan-3-one, 5α-pregnane-3,20-dione, 5β-pregnane-3,20-dione, 3-oxo-5β-cholanoic acid and 7α-hydroxy-5α-cholestan-3-one.
I, Björkhem, K, Einarsson, G, Hellers, K, Wikvall   +3 more
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Characterization of metronidazole metabolism by human liver microsomes

Biochemical Pharmacology, 1991
The metabolism of metronidazole was studied in microsomes isolated from livers of human kidney donors. The formation of the major in vivo metabolite, hydroxymetronidazole, proceeded according to biphasic kinetics, suggesting the involvement of at least two enzymatic sites.
S, Loft, S V, Otton, M S, Lennard, G T, Tucker, H E, Poulsen   +4 more
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Variation in glucuronidation of lamotrigine in human liver microsomes

Xenobiotica, 2009
Lamotrigine (LTG), a diaminotriazine anti-epileptic, is principally metabolized at the 2-position of the triazine ring to form a quaternary ammonium glucuronide (LTGG) by uridine glucuronosyl transferease (UGT) 1A3 and UGT1A4. It has been hypothesized that glucuronidation of anti-epileptic drugs is spared with age, despite a known decrease in liver ...
U A, Argikar, R P, Remmel
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Metabolism of Ketamine Stereoisomers by Human Liver Microsomes

Anesthesiology, 1992
Ketamine is used clinically as a racemic mixture of optical isomers that differ in their analgesic properties and psychomimetic effects. Administered individually, or together as the racemate, ketamine enantiomers differ in their hepatic clearance and duration of anesthetic effect.
E D, Kharasch, R, Labroo
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In Vitro Metabolism of Isoliquiritigenin by Human Liver Microsomes

Drug Metabolism and Disposition, 2008
Isoliquiritigenin (2',4',4-trihydroxychalcone), a chalcone found in licorice root and other plants, has shown potent antitumor, antioxidant, and phytoestrogenic activity in vitro. In preparation for in vivo studies, the metabolism of isoliquiritigenin by human liver microsomes was investigated, and seven phase 1 metabolites were identified. In addition
Jian, Guo, Dongting, Liu, Dejan, Nikolic, Dongwei, Zhu, John M, Pezzuto, Richard B, van Breemen   +5 more
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Inactivation of CYP3A4 by Benzbromarone in Human Liver Microsomes

Drug Metabolism Letters, 2016
Benzbromarone is a uricosuric drug in current clinical use that can cause serious hepatotoxicity. Chemically reactive and/or cytotoxic metabolites of benzbromarone have been identified; however there is a lack of available information on their role in benzbromarone hepatotoxicity.
Yasuhiro, Masubuchi, Shinji, Kondo
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