Results 221 to 230 of about 50,120 (254)
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Variation in glucuronidation of lamotrigine in human liver microsomes
Xenobiotica, 2009Lamotrigine (LTG), a diaminotriazine anti-epileptic, is principally metabolized at the 2-position of the triazine ring to form a quaternary ammonium glucuronide (LTGG) by uridine glucuronosyl transferease (UGT) 1A3 and UGT1A4. It has been hypothesized that glucuronidation of anti-epileptic drugs is spared with age, despite a known decrease in liver ...
U A, Argikar, R P, Remmel
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FACTORS INFLUENCING MIDAZOLAM HYDROXYLATION ACTIVITY IN HUMAN LIVER MICROSOMES
Drug Metabolism and Disposition, 2006The cytochrome P450 3A (CYP3A) subfamily (mainly CYP3A4 and CYP3A5) is responsible for metabolizing approximately half of currently marketed drugs, but with considerable interindividual variability in expression and function. To investigate factors contributing to this variability, rates of midazolam (MDZ) 1'-hydroxylation and CYP3A4 and CYP3A5 protein
Ping, He +3 more
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Characterization of 1′-Hydroxymidazolam Glucuronidation in Human Liver Microsomes
Drug Metabolism and Disposition, 2008Midazolam is a potent benzodiazepine derivative with sedative, hypnotic, anticonvulsant, muscle-relaxant, and anxiolytic activities. It undergoes oxidative metabolism catalyzed almost exclusively by the CYP3A subfamily to a major metabolite, 1'-hydroxymidazolam, which is equipotent to midazolam.
Bing, Zhu +5 more
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Metabolism of benz[a]anthracene by human liver microsomes
Cancer Letters, 1994The metabolism of benz[a]anthracene (BA) by human hepatic microsomes was investigated. Only dihydrodiols were observed when BA was the substrate. No tetrahydrotetrols were detected, indicating lack of diol epoxide formation. The BA-dihydrodiols identified by GCMS analysis and comparison to authentic standards were BA-8,9-dihydrodiol (42.4% of total ...
Y, Sahali +3 more
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Lindane metabolism by human and rat liver microsomes†
Xenobiotica, 19821. Human liver microsomes convert lindane (gamma isomer of 1,2,3,4,5,6-hexachlorocyclohexane) to four major primary metabolites; gamma-1,2,3,4,5,6-hexachlorocyclohex-1-ene (3,6/4,5-HCCH), gamma-1,3,4,5,6-pentachlorocyclohex-1-ene (3,6/4,5-PCCH), beta-1,3,4,5,6-pentachlorocyclohex-1-ene (3,4,6/5-PCCH), and 2,4,6-trichlorophenol (2,4,6-TCP); and two ...
J F, Fitzloff, J, Portig, K, Stein
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NADPH-Dependent Metabolism of Estrone by Human Liver Microsomes
The Journal of Pharmacology and Experimental Therapeutics, 2002We characterized the NADPH-dependent metabolism of estrone (E1) by liver microsomes of 21 male and 12 female human subjects. The structures of 11 hydroxylated or keto metabolites of E1 formed by human liver microsomes were identified by chromatographic and mass spectrometric analyses.
Anthony J, Lee +4 more
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Human liver microsomal drug metabolism
Biochemical Pharmacology, 1970F J, Darby, W, Newnes, D A, Price Evans
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Metabolism of phencyclidine by human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals, 1997These studies examined in vitro metabolism of phencyclidine (PCP) in a series of human liver microsomes (N = 10). Each sample was characterized for cytochrome P450 (CYP) content and for CYP1A, CYP2A, CYP2C, CYP2D, CYP2E, CYP3A, CYP4A, and lauric acid 11-hydroxylation metabolic activities.
E M, Laurenzana, S M, Owens
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OXIDATIVE DRUG METABOLISM IN HUMAN LIVER MICROSOMES
The Journal of Pharmacology and Experimental Therapeutics, 1971E B, Nelson +3 more
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Colchicine biotransformation by human liver microsomes
Biochemical Pharmacology, 1997Tomonori Tateishi +4 more
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