Results 201 to 210 of about 27,101 (273)

In Vitro Metabolism Study of Seongsanamide A in Human Liver Microsomes Using Non-Targeted Metabolomics and Feature-Based Molecular Networking. [PDF]

Pharmaceutics, 2021
Wu Z, Kim GJ, Park SY, Shon JC, Liu KH, Choi H.   +5 more
europepmc   +1 more source

A Phase 1 Microtracer Study Evaluating the Mass Balance, Excretion, and Pharmacokinetics of Osivelotor in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Osivelotor (GBT021601) is an orally bioavailable, small molecule hemoglobin polymerization inhibitor in clinical development for the treatment of sickle cell disease (SCD). In this Phase 1 study, the disposition of osivelotor was assessed using accelerator mass spectrometry (AMS) after a single oral 200‐mg dose containing a microtracer amount ...
Eric I. Zimmerman, Ernesto Callegari, Raman Sharma, Adeyemi Adenola, Jessica Volpe, Karthik Seetharaman, Chenghong Zhang, Kenneth Duchin, Gregory S. Walker   +8 more
wiley   +1 more source

Probe substrates assay estimates the effect of polyphyllin H on the activity of cytochrome P450 enzymes in human liver microsomes. [PDF]

Pharmacol Res Perspect
Wang E, Wang M, Gao M.
europepmc   +1 more source

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup, Wanvisa Udomsinprasert   +1 more
wiley   +1 more source

Nanobioelectrocatalysis Using Human Liver Microsomes and Cytochrome P450 Bactosomes: Pyrenyl-Nanocarbon Electrodes. [PDF]

ACS Appl Bio Mater
Premaratne G, Niroula J, Moulton JT, Krishnan S.   +3 more
europepmc   +1 more source

Comprehensive Investigation of Stereoselective Food Drug Interaction Potential of Resveratrol on Nine P450 and Six UGT Isoforms in Human Liver Microsomes. [PDF]

Pharmaceutics, 2021
Ji SB, Park SY, Bae S, Seo HJ, Kim SE, Lee GM, Wu Z, Liu KH.   +7 more
europepmc   +1 more source

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Myuri Ruthirakuhan, Ameer Y. Taha, Walter Swardfager   +2 more
wiley   +1 more source

Metabolic Stability and Metabolite Identification of N-Ethyl Pentedrone Using Rat, Mouse and Human Liver Microsomes. [PDF]

Pharmaceutics
Godoi AB, Antunes NJ, Cunha KF, Martins AF, Huestis MA, Costa JL.   +5 more
europepmc   +1 more source

Inhibitory Effects of Schisandra Lignans on Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyl Transferases in Human Liver Microsomes. [PDF]

Pharmaceutics, 2021
Seo HJ, Ji SB, Kim SE, Lee GM, Park SY, Wu Z, Jang DS, Liu KH.   +7 more
europepmc   +1 more source

An Ultra-Fast Validated Green UPLC-MS/MS Approach for Assessing Revumenib in Human Liver Microsomes: In Vitro Absorption, Distribution, Metabolism, and Excretion and Metabolic Stability Evaluation. [PDF]

Medicina (Kaunas)
Attwa MW, Abdelhameed AS, Kadi AA.
europepmc   +1 more source