Results 51 to 60 of about 107,130 (257)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, Volume 20, Issue 8, Page 2054-2084, August 2026.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Automatic Eye Winks Interpretation System for Human-Machine Interface

EURASIP Journal on Image and Video Processing, 2007
This paper proposes an automatic eye-wink interpretation system for human-machine interface to benefit the severely handicapped people. Our system consists of (1) applying the support vector machine (SVM) to detect the eyes, (2) using the template ...
Hwang Wen-Liang, Wei-Gang Che, Huang Chung-Lin   +2 more
doaj   +2 more sources

Human Machine Interface [PDF]

Journal of Electrical & Electronic Systems, 2016
An industrial control user interface N€rоvN–dеN• а flexible, extensible architecture fоr thе provision оf real-time process data tо а state-of-the-art user interface, uN•N–ng MSHTML аN• thе underlying rendering engine. Thе architecture оf thе interface N€rоvN–dеN• а user interface thаt N–N• designed tо harness key industry standard ...
openaire   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Advances in Human–Machine Systems, Human–Machine Interfaces and Human Wearable Device Performance

Applied Sciences
The human–machine system (HMS) and human–machine interface (HMI) are among the top factors that affect the development of advanced systems, equipment, and products [...]
Kai Way Li, Lu Peng
doaj   +1 more source

Formal Analysis and Design of Supervisor and User Interface Allowing for Non-Deterministic Choices Using Weak Bi-Simulation

Applied Sciences, 2018
In human machine systems, a user display should contain sufficient information to encapsulate expressive and normative human operator behavior. Failure in such system that is commanded by supervisor can be difficult to anticipate because of unexpected ...
Shazada Muhammad Umair Khan, Wenlong He
doaj   +1 more source

Application of artificial bee colony algorithm and back propagation neural network in color evaluation of human–machine interaction interfaces

Engineering Reports, 2022
People prefer an attractive human–machine interaction interface, and color is an important factor affecting attractiveness. Therefore, to evaluate the color of human–machine interaction interfaces, a back propagation neural network (BPNN) optimized by ...
Li Deng, Fuduo Deng, Guohua Wang
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source