Results 61 to 70 of about 10,829,930 (289)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Formal Analysis and Design of Supervisor and User Interface Allowing for Non-Deterministic Choices Using Weak Bi-Simulation

open access: yesApplied Sciences, 2018
In human machine systems, a user display should contain sufficient information to encapsulate expressive and normative human operator behavior. Failure in such system that is commanded by supervisor can be difficult to anticipate because of unexpected ...
Shazada Muhammad Umair Khan, Wenlong He
doaj   +1 more source

Human-Machine Interface based on Electrocutaneous Menu

open access: yes, 2015
Repository for the paper Gonzalez-Vargas J, Dosen S, Amsuess S, Yu W, Farina D. "Human-Machine Interface based on Electrocutaneous Menu"  PLOS ONE.
Jose Gonzalez (736784)
core   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Energy-Harvesting Smart Tiles for Human–Machine Interface Applications

open access: yesProceedings
In this work, a human–machine interface with energy harvesting capabilities was developed and a modular floor made of tiles equipped with piezoelectric elements was produced.
Alessandro Zompanti   +5 more
doaj   +1 more source

Design and implementation of visible human-machine interface for trajectory tracking in agriculture vehicle navigation

open access: yes, 2012
This paper designs a visible human-machine interface for field computer in an agriculture vehicle navigation control system. Field computer, with the function of system configuration, vehicle configuration, steering configuration, job management, path ...
Liu XG(刘晓光)   +4 more
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Design and Implementation of Visible Human-machine Interface for Trajectory Tracking in Agro-machinery Navigation

open access: yes, 2011
This paper designs a visible human-machine interface for field computer in an agriculture vehicle navigation control system. Field computer, with the function of system configuration, vehicle configuration, steering configuration, job management, path ...
Liu XG(刘晓光)   +4 more
core  

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