Results 51 to 60 of about 3,474,590 (264)
Human genetics in oral medicine: A review
Journal of Indian Academy of Oral Medicine and Radiology, 2014 In this modern era, oral health practice has become evidence-based dentistry. Genes are hereditary blueprints of human beings. Studies at the molecular levels have revolutionized maxillofacial disorders, and genomic information has done wonders to the ...
Manas Gupta +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Fakes and chemicals: indigenous medicine in contemporary Kenya and implications for health equity
International Journal for Equity in Health, 2020 Background Access to effective biomedical treatments for humans and livestock in Kenya is far from universal. Indigenous healing has a significant role to play in contemporary society in Kenya, yet access is not the only reason for this.
Olivia Howland
doaj +1 more source
AMA Journal of Ethics, 2004 The journal editor introduces a theme issue on medicine and human rights by calling on physicians to speak out against worldwide human rights abuses. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
iScienceSummary: Accurate thermal management in hypoxic and altered-pressure environments is essential, as variations in ambient pressure and oxygen availability can modify human metabolic heat production.
Qing Zhang +6 more
doaj +1 more source
Holistic medicine: A new medical system based on body constitution and functional status
Journal of Traditional Chinese Medical Sciences, 2017 At present, modern medicine is a scientific system in the following sense: it uses observation of static states and analysis of single factors to determine the relationship between structure and function in the human body in states of health and disease.
Bing Yuan
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source