Results 111 to 120 of about 1,389,274 (311)

Effect of oxygen tension on the amino acid utilisation of human embryonic stem cells

, 2014
Background/aims: human embryonic stem cells (hESCs) are a potential source of cells for treatment of many degenerative diseases, but in culture have a propensity to spontaneously differentiate, possibly due to suboptimal conditions. Culture at low oxygen
Christensen, David R., David R. Christensen, Calder, Philip C., Houghton, Franchesca D., Philip C. Calder, Franchesca D. Houghton   +5 more
core   +1 more source

Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms. [PDF]

, 2007
BACKGROUND: There is a wide variation in susceptibility to health effects of arsenic, which, in part, may be due to differences in arsenic metabolism.
Eugen Gurzau, Vahter, Marie, Gurzau, Eugen, Rajiv Kumar, Goessler, Walter, Ranjit Thirumaran, Leonardi, Giovanni, Kumar, Rajiv, Marie Vahter, Tony Fletcher, Anna-Lena Lindberg, Koppova, Kvetoslava, Giovanni Leonardi, Fletcher, Tony, Walter Goessler, Peter Rudnai, Kvetoslava Koppova, Rudnai, Peter, Thirumaran, Ranjit, Lindberg, Anna-Lena   +19 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Plasma apolipoprotein changes in the triglyceride-rich lipoprotein fraction of human subjects fed a fat-rich meal

Journal of Lipid Research, 1988
Twenty two subjects (9 males, 13 females) were fed a fat-rich meal (1 g of fat/kg body weight). Triglyceride-rich lipoproteins (TRL) were isolated by ultracentrifugation (d less than 1.006 g/ml) from blood drawn 0, 3, 6, 9, and 12 hr after the meal ...
J S Cohn, J R McNamara, S D Cohn, J M Ordovas, E J Schaefer   +4 more
doaj   +1 more source

Neurosteroid metabolism in the human brain [PDF]

European Journal of Endocrinology, 2001
This review summarizes the current knowledge of the biosynthesis of neurosteroids in the human brain, the enzymes mediating these reactions, their localization and the putative effects of neurosteroids. Molecular biological and biochemical studies have now firmly established the presence of the steroidogenic enzymes cytochrome P450 cholesterol side ...
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

In Vitro Metabolism of Medroxyprogesterone Acetate with Human Liver Microsome and Comparison with Rat,Minipig Liver Microsmes and Recombinant Human CYP3A4

, 2006
Objective: To study the metabolism of medroxyprogesterone acetate (MPA) in human liver microsomes and compare the metabolim profile with rat, minipig liver mcirosomes and recombinant human CYP3A4.
张江伟, 李巍, 刘勇, 杨凌
core  

Human fetal amino acid metabolism at term gestation

, 2009
Knowledge on human fetal amino acid (AA) metabolism, largely lacking thus far, is pivotal in improving nutritional strategies for prematurely born infants.
van den Akker, Chris H. P., Vermes, Andras, Steegers, Eric A. P., van Goudoever, Johannes B., Schierbeek, Henk, Van Den Akker, Chris H.P., Steegers, Eric A.P., Dorst, Kristien Y., Schoonderwaldt, Ernst M., Duvekot, Johannes J.   +9 more
core   +1 more source

Serum metabolic fingerprinting for diagnosis and therapeutic applications of ovarian endometriosis

iScience
Summary: Ovarian endometriosis (OvE) is a gynecological disorder with endometrial tissue in the ovaries, for which effective non-invasive diagnosis and curative treatments are currently lacking.
Chencheng Dai, Yiwei Cao, Yiran Xu, Moyuan Li, Guangquan Liu, Sujuan Xu, Nuo Ye, Changxiang Shi, Tiantian Fan, Pengfei Xu, Xuemei Jia   +10 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source