Results 121 to 130 of about 1,389,274 (311)

Bovine liver slices combined with an androgen transcriptional activation assay: an in-vitro model to study the metabolism and bioactivity of steroids [PDF]

, 2010
Previously we described the properties of a rapid and robust yeast androgen bioassay for detection of androgenic anabolic compounds, validated it, and showed its added value for several practical applications.
S. Van Kuijk, Kuijk, S., J. H. Riethoff-Poortman, Rijk, J.C.W., T. F. H. Bovee, Wang, S., Peijnenburg, A.A.C.M., Poortman, J.H., Bovee, T.F.H., S. Wang, J. C. W. Rijk, A. A. C. M. Peijnenburg   +11 more
core   +1 more source

Fiber enrichment is not superior to dietary monitoring in MASLD: A dual-center, double-blind, placebo-controlled trial

iScience
Summary: Dietary fiber enrichment may modulate intestinal microbiota and positively impact metabolic dysfunction-associated steatotic liver disease (MASLD).
Annette Brandt, Timur Yergaliyev, Emina Halibasic, Aline Cyba, Julius W. Jaeger, Rongpeng Gong, Angélica Hernández-Arriaga, Carolin Victoria Schneider, Wilhelm Sjöland, Antonio Molinaro, Michael Trauner, Christian Trautwein, Amélia Camarinha-Silva, Ina Bergheim, Kai Markus Schneider   +14 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. [PDF]

, 2014
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions.
Opperdoes, F.R. (Fred), van Hellemond, JJ, de Koning, HP, Nes, D. W.,, Nayak, A.,, Silva-Franco, F.,, de, Koning HP, Wyllie, S, Ebikeme, C., van Hellemond, Jaap; id_orcid, van Hellemond, J. J.,, Crouch, Kathryn, Ferguson, Michael A.J., Nolan, D. P.,, Bütikofer, P. (Peter), Nolan, Derek P., Barrett, Michael P, Ebikeme, C. (Charles), Olsen, C, De Koning, H.P. (Harry P.), Jourdan, F., Vinson, F. (Florence), Bütikofer, P, Ferguson, MA, Ferguson, Michael A. J., Mäser, P, Butikofer, P., Opperdoes, F. R., Breitling, R., Nayak, A, Achcar, F., Smith, Terry K., Ferguson, MAJ, Boshart, M., Boshart, M, Denise, H., Logan-Klumpler, F. J.,, Cattanach, A. M.,, Taylor, M. C., Wyllie, S. (Susan), Hertz-Fowler, C., Creek, D.J. (Darren J.), Silva-Franco, F, Nes, DW, LS Biochemie van parasieten, Smith, TK, Kerkhoven, E. J., Crouch, K, Wyllie, S., Merlet, B.,, Vincent, Isabel M., Olsen, C., Tielens, A.G.M. (Lodewijk), Regenerative Medicine, Stem Cells & Cancer, Merlet, Benjamin, Taylor, M. C.,, Cottret, L., Creek, DJ, Opperdoes, FR, Ferguson, Michael AJ, Berriman, M, Opperdoes, Fred R., Logan-Klumpler, FJ, Achcar, Fiona, Barrett, M. P., Breitling, R, Urbaniak, Michael D., Denise, H. (Hubert), Fairlamb, Alan H, Merlet, B, Boshart, Michael, Fairlamb, A. H.,, Wilkinson, SR, Taylor, MC, Urbaniak, Michael D, Crouch, K.,, Breitling, R.,, Vincent, I.M. (Isabel M.), Tielens, Aloysius G M, Breitling, R. (Rainer), Boshart, M. (Michael), de Koning, Harry P, Smith, T. K.,, Michels, PA, de Koning, H. P.,, Nes, David W., Ginger, ML, Butikofer, P.,, Barrett, M. P.,, Hertz-Fowler, Christiane, Bannerman-Chukualim, B., Hertz-Fowler, C.,, Fairlamb, Alan H., Ebikeme, C, Michels, Paul A. M., Tielens, A. G. M., Taylor, Martin C, Nolan, Derek P, Maeser, P, Boshart, M.,, Taylor, Martin C., Hertz-Fowler, C, Nayak, A. (Archana), Shameer, Sanu, Ferguson, M. A. J.,, Tielens, Aloysius G.M., Cattanach, Amy M., Crouch, K., Fairlamb, Alan H.; id_orcid, Urbaniak, MD, Tielens, Lodewijk, Jourdan, F, Ferguson, Michael A. J.; id_orcid, Berriman, M., Bringaud, Frédéric, Bannerman-Chukualim, B. (Bridget), Wyllie, S.,, Silva-Franco, F. (Fatima), Wilkinson, S. R., Silva-Franco, F., Shameer, S, Bringaud, F. (Frédéric), Bannerman-Chukualim, Bridget, Michels, Paul A.M., Ginger, M. L.,, Nes, David W, Shameer, S.,, van Hellemond, Jaap J., Ferguson, M. A. J., van Hellemond, J. J., Urbaniak, M.D. (Michael D.), Nolan, D.P. (Derek P.), Wilkinson, S. R.,, Creek, Darren J., Merlet, B., Mäser, Pascal, Michels, Paul AM, Cattanach, A.M. (Amy M.), Tielens, AG, Barrett, Michael P., Jourdan, Fabien, Wyllie, Susan, Fairlamb, AH, Bringaud, F.,, Kerkhoven, Eduard J, Maeser, Pascal, Vinson, F., Bringaud, F., Creek, D. J., Berriman, M. (Matthew), Tielens, AGM, Logan-Klumpler, Flora J, Shameer, S. (Sanu), Achcar, F.,, Michels, P. A. M., Koning, Harry P. de, Logan-Klumpler, F. J., Fairlamb, A. H., Vincent, IM, Nayak, A., Logan-Klumpler, Flora J., Bütikofer, Peter, Shameer, S., Olsen, C. (Christian), Cottret, Ludovic, Ebikeme, Charles, Cottret, L.,, Nolan, DP, Michels, PAM, Tielens, A. G. M.,, Opperdoes, F. R.,, Silva-Franco, Fatima, Kerkhoven, E.J. (Eduard), Berriman, M.,, Maser, P.,, van Hellemond, Jaap J, Urbaniak, M. D., Ginger, M.L. (Michael L.), Michels, P.A.M. (Paul), Kerkhoven, EJ, Creek, D. J.,, Maser, P., Mäser, P. (Pascal), Kerkhoven, Eduard J., Merlet, B. (Benjamin), Fairlamb, A.H. (Alan H.), Achcar, F. (Fiona), Smith, T.K. (Terry K.), de Koning, H. P., Urbaniak, M. D.,, Nes, D. (DavidW.), Crouch, K. (Kathryn), Denise, H, Bannerman-Chukualim, B.,, Jourdan, F. (Fabien), Ginger, M. L., Berriman, Matthew, Tielens, Aloysius GM, Jourdan, F.,, Achcar, F, Ebikeme, C.,, Olsen, Christian, Wilkinson, Shane R, Cottret, L. (Ludovic), Hertz-Fowler, C. (Christiane), Hellemond, Jaap J. van, Kerkhoven, Eduard,, Ginger, Michael L., Ferguson, M.A.J. (Michael A. J.), Cottret, L, Vincent, I. M., Nes, D. W., Barrett, MP, de Koning, Harry P., Michels, P. A. M.,, Cattanach, Amy M, Cattanach, AM, Hellemond, J.J. (Jaap) van, Michels, Paul A M, Nolan, D. P., Wilkinson, S.R. (Shane R.), Vinson, F.,, Wilkinson, Shane R., Breitling, Rainer, Creek, Darren J, Barrett, M.P. (Michael P.), B&C BRC-SIB-TR, Tielens, Lodewijk; id_orcid, Vinson, Florence, Tielens, Aloysius G. M., Bringaud, F, Vincent, Isabel M, Logan-Klumpler, F.J. (Flora J.), Opperdoes, Fred R, Denise, H.,, Vincent, I. M.,, Olsen, C.,, van, Hellemond JJ, Ginger, Michael L, Kerkhoven, Eduard, Denise, Hubert, Smith, T. K., Taylor, M.C. (Martin C.), Vinson, F, Nayak, Archana, Ferguson, Michael A J, van Hellemond, Jaap, Smith, Terry K, Bannerman-Chukualim, B, Cattanach, A. M.   +249 more
core   +1 more source

Caloric restriction modifies small RNA profiles and engages age-related molecular pathways in the CALERIE trial

iScience
Summary: Caloric restriction (CR) extends lifespan and enhances healthspan across species. In humans, the CALERIE Phase 2 trial demonstrated that CR improves inflammation, cardiometabolic health, and molecular aging.
Melissa C. Orenduff, Kim M. Huffman, Daniel W. Belsky, Carl F. Pieper, William E. Kraus, Virginia B. Kraus   +5 more
doaj   +1 more source

Lipoprotein lipase genotypes for a common premature termination codon mutation detected by PCR-mediated site-directed mutagenesis and restriction digestion.

Journal of Lipid Research, 1992
We have developed a procedure for the determination of a common mutation in exon 9 of the human lipoprotein lipase (LPL) gene. The mutation is due to a C-G transversion which creates a premature termination codon (Ser447-Ter) and results in a truncated ...
J Stocks, JA Thorn, DJ Galton
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism.

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
John Dixon, Philips, B, Dixon, J, Lane, K, Macphee, I, Katie Lane, Barbara Philips, Iain MacPhee   +7 more
core   +1 more source

Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice

Scientific Reports, 2017
The role of dietary fibre and short-chain fatty acids (SCFA) in obesity development is controversially discussed. Here, we investigated how various types of dietary fibre and different SCFA ratios affect metabolic syndrome-related disorders.
Karolin Weitkunat, Christin Stuhlmann, Anna Postel, Sandra Rumberger, Maria Fankhänel, Anni Woting, Klaus Jürgen Petzke, Sabrina Gohlke, Tim J. Schulz, Michael Blaut, Susanne Klaus, Sara Schumann   +11 more
doaj   +1 more source

Lipolytic effects on diacylglycerol accumulation in human adipose tissue in vitro.

Journal of Lipid Research, 1990
When fragments of rat or human adipose tissue, or isolated adipocytes, are incubated with [14C]glucose in vitro, [14C]diacylglycerol accumulates rapidly: it comprises 20-50% of newly synthesized (14C-labeled) acylglycerols, compared to less than 1 ...
NK Edens, RL Leibel, J Hirsch
doaj   +1 more source