Results 121 to 130 of about 2,261,504 (355)

Caloric restriction modifies small RNA profiles and engages age-related molecular pathways in the CALERIE trial

iScience
Summary: Caloric restriction (CR) extends lifespan and enhances healthspan across species. In humans, the CALERIE Phase 2 trial demonstrated that CR improves inflammation, cardiometabolic health, and molecular aging.
Melissa C. Orenduff, Kim M. Huffman, Daniel W. Belsky, Carl F. Pieper, William E. Kraus, Virginia B. Kraus   +5 more
doaj   +1 more source

Lipoprotein lipase genotypes for a common premature termination codon mutation detected by PCR-mediated site-directed mutagenesis and restriction digestion.

Journal of Lipid Research, 1992
We have developed a procedure for the determination of a common mutation in exon 9 of the human lipoprotein lipase (LPL) gene. The mutation is due to a C-G transversion which creates a premature termination codon (Ser447-Ter) and results in a truncated ...
J Stocks, JA Thorn, DJ Galton
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice

Scientific Reports, 2017
The role of dietary fibre and short-chain fatty acids (SCFA) in obesity development is controversially discussed. Here, we investigated how various types of dietary fibre and different SCFA ratios affect metabolic syndrome-related disorders.
Karolin Weitkunat, Christin Stuhlmann, Anna Postel, Sandra Rumberger, Maria Fankhänel, Anni Woting, Klaus Jürgen Petzke, Sabrina Gohlke, Tim J. Schulz, Michael Blaut, Susanne Klaus, Sara Schumann   +11 more
doaj   +1 more source

Lipolytic effects on diacylglycerol accumulation in human adipose tissue in vitro.

Journal of Lipid Research, 1990
When fragments of rat or human adipose tissue, or isolated adipocytes, are incubated with [14C]glucose in vitro, [14C]diacylglycerol accumulates rapidly: it comprises 20-50% of newly synthesized (14C-labeled) acylglycerols, compared to less than 1 ...
NK Edens, RL Leibel, J Hirsch
doaj   +1 more source

Effects of intermittent hydrostatic pressure and BMP‐2 on osteoarthritic human chondrocyte metabolism in vitro [PDF]

, 2010
Robert L. Smith, Derek P. Lindsey, Lakshmi Dhulipala, Alex H. S. Harris, Stuart B. Goodman, William J. Maloney   +5 more
openalex   +1 more source

Progress of m6A Methylation in Lipid Metabolism in Humans and Animals [PDF]

, 2022
Zimeng Xin, Tianying Zhang, Qinyue Lu, Zhangping Yang, Zhi Chen   +4 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Comparison of deuterated leucine, valine, and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics

Journal of Lipid Research, 1990
The production rates of apolipoprotein (apo)B-100 in very low density lipoprotein and in low density lipoprotein and apolipoprotein A-I in high density lipoprotein were determined using a primed-constant infusion of [5,5,5,-2H3]leucine, [4,4,4,-2H3 ...
AH Lichtenstein, JS Cohn, DL Hachey, JS Millar, JM Ordovas, EJ Schaefer   +5 more
doaj   +1 more source

The metabolism of 2‐fluoro‐2‐deoxy‐d‐glucose in human chondrocytes and its incorporation into keratan sulfate proteoglycans [PDF]

, 1994
Gönna Fedders, R. Kock, Eddy Van de Leur, H. Greiling   +3 more
openalex   +1 more source