Results 31 to 40 of about 9,306,580 (247)

Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins

Nature Communications, 2022
The human metapneumovirus (hMPV) fusion (F) protein is essential for viral entry and is a key target of neutralizing antibodies and vaccine development.
C. Hsieh, Scott A. Rush, C. Palomo, Chia-Wei Chou, Whitney Pickens, V. Mas, Jason S. McLellan   +6 more
semanticscholar   +1 more source

Safety and Immunogenicity of an mRNA-Based Human Metapneumovirus and Parainfluenza Virus Type 3 Combined Vaccine in Healthy Adults

Open Forum Infectious Diseases, 2022
Background Human metapneumovirus (hMPV) and parainfluenza virus type 3 (PIV3) cause respiratory tract illness in children and the elderly. No licensed vaccines are available.
A. August, C. Shaw, Heather Lee, C. Knightly, Shiva Kalidindia, L. Chu, B. Essink, W. Seger, T. Zaks, I. Smolenov, Lori Panther   +10 more
semanticscholar   +1 more source

Incidence and viral aetiologies of acute respiratory illnesses (ARIs) in the United States: a population-based study. [PDF]

, 2016
We conducted prospective, community-wide surveillance for acute respiratory illnesses (ARIs) in Rochester, NY and Marshfield, WI during a 3-month period in winter 2011.
Albertin, C, Blumkin, A, Donahue, JG, Gallivan, S, Lofthus, GK, Schnabel, KC, Shay, DK, Szilagyi, PG, Thompson, MG, Treanor, JJ   +9 more
core   +1 more source

Human Metapneumovirus Reinfection in Aged Mice Recapitulates Increased Disease Severity in Elderly Humans Infected with Human Metapneumovirus

ImmunoHorizons, 2023
Human metapneumovirus (HMPV) is a leading cause of respiratory infection in adults >65 y. Nearly all children worldwide are seropositive for HMPV by age 5 y, but reinfections occur throughout life, and there is no licensed vaccine.
Olivia B. Parks, T. Eddens, Yu Zhang, T. Oury, A. McElroy, John V. Williams   +5 more
semanticscholar   +1 more source

Human Metapneumovirus in Severe Respiratory Syncytial Virus Bronchiolitis

Emerging Infectious Diseases, 2003
Reverse transcription-polymerase chain reaction was used to detect segments of the M (matrix), N (nucleoprotein), and F (fusion) genes of human metapneumovirus in bronchoalveolar fluid from 30 infants with severe respiratory syncytial virus bronchiolitis.
Julie Greensill, Paul S. McNamara, Winifred Dove, Brian Flanagan, Rosalind L. Smyth, C. Anthony Hart   +5 more
doaj   +1 more source

An Unusual Resurgence of Human Metapneumovirus in Western Australia Following the Reduction of Non-Pharmaceutical Interventions to Prevent SARS-CoV-2 Transmission

Viruses, 2022
Non-pharmaceutical interventions (NPIs) to reduce SARS-CoV-2 transmission disrupted respiratory virus seasonality. We examined the unusual return of human metapneumovirus (hMPV) in Western Australia following a period of absence in 2020. We analysed hMPV
D. Foley, C. Sikazwe, C. Minney-Smith, Timo Ernst, H. Moore, M. Nicol, David W Smith, A. Levy, Christopher C Blyth   +8 more
semanticscholar   +1 more source

Emergence and Potential Extinction of Genetic Lineages of Human Metapneumovirus between 2005 and 2021

mBio, 2022
Human metapneumovirus (HMPV) is one of the major causative agents of human respiratory tract infections. Monitoring of virus evolution could aid toward the development of new antiviral treatments or vaccine designs.
K. Groen, S. van Nieuwkoop, A. Meijer, B. van der Veer, J. V. van Kampen, P. Fraaij, R. Fouchier, B. G. van den Hoogen   +7 more
semanticscholar   +1 more source

Human Metapneumovirus and Status Epilepticus

Pediatric Neurology Briefs, 2014
Investigators at Cincinnati Children's Hospital, OH, report 2 toddlers, ages 15 and 18 months, with human metapneumovirus (hMPV) infection who presented in status epilepticus and later developed respiratory failure.
J Gordon Millichap, John J Millichap
doaj   +1 more source

Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections [PDF]

, 2017
Background: Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B.
Agricola, Eleonora, Buttinelli, Gabriele, Campagna, Ilaria, Carsetti, R., Concato, C., DI MATTIA, Greta, Fedele, Giorgio, Ferretti, Beatrice, Frassanito, Antonella, Gesualdo, Francesco, Gonfiantini, Michaela Veronika, Marcellini, Valentina, Midulla, Fabio, Nenna, Raffaella, Nicolai, Ambra, Pandolfi, Elisabetta, Pierangeli, Alessandra, Russo, Luisa, Schiavoni, I., Stefanelli, P., Tozzi, A. E., Vennarucci, Valentina Spuri, Villani, Alberto   +22 more
core   +1 more source

Human metapneumovirus in hospitalized children with acute respiratory tract infections in Beijing, China.

Infection, Genetics and Evolution, 2022
BACKGROUND This study aims to described the epidemiology and genotypic diversity of Human metapneumovirus (HMPV) and the impact of SARS-CoV-2 on the prevalence of HMPV in hospitalized children with Acute respiratory tract infections (ARTIs) in Beijing ...
Shanshan Cong, Chao Wang, Tian-li Wei, Zhi‐ping Xie, Yiman Huang, Jingjing Tan, Aijun Chen, Fenlian Ma, Li-shu Zheng   +8 more
semanticscholar   +1 more source