Results 141 to 150 of about 555,946 (268)
Advanced Science, EarlyView.Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang +13 more
wiley +1 more source
Advanced Science, EarlyView.In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu +7 more
wiley +1 more source
Connecting Grazing, Forage, and Milk Metabolomes to Enhance Consumer Health [PDF]
The objective of this work was to explore the effect of taxonomically and phytochemically rich swards, as opposed to ‘status quo’ monoculture of ryegrass and white clover swards, on animals and milk, by assessing the metabolomic profile of plant and milk
Philip Wescombe +2 more
core +1 more source
Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism
Frontiers in NutritionIntroductionHuman milk-derived probiotics are beneficial bacteria that provide gestational health benefits, for both pregnant women and their offspring. The study aims to investigate whether the administration of human milk-derived probiotic L. plantarum
Bin Liu +15 more
doaj +1 more source
Advanced Science, EarlyView.Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu +12 more
wiley +1 more source
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Study on Food Antigens Transferred into Breast Milk [PDF]
, 2007 74検体の母乳中に移行した食物抗原(オボムコイド、オボアルブミン、β一ラクトグロブリン、カゼイン及びグリアジン)をELISA法にて分析した。その結果、母乳中に各食物抗原は、11-34%の頻度、12.8-44.3ng/m1の最大濃度で存在していた。母乳中に移行した食物抗原の濃度は母乳のIgA濃度と正相関が認められ、5種類の食物抗原特異的IgAが全ての母乳に存在していた。これらの結果より、母乳中に移行した食物抗原はIgAと免疫複合体を形成していることが推測された。また ...
Isomura, Haruhiko, Totani, Masayuki
core +1 more source
Advanced Science, EarlyView.SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
Lactoferrin is responsible for the fungistatic effect of human milk [PDF]
, 2000 Human milk has recognized anti-microbial effects and it has been repeatedly shown that breast-fed infants have fewer and less severe infections than formula-fed infants. While most studies have focused on anti-bacterial and anti-viral activities few have
Lagerqvist, Carina, +3 more
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