Results 201 to 210 of about 8,697,028 (307)

Beta-casein in human milk is associated with infant stool frequency: A pilot proteomics study. [PDF]

Physiol Rep
Li ZH, Xie ZR, Li M, Xiong JJ, Liu M, Huang YK.   +5 more
europepmc   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Human milk and breastfeeding support in United States paediatric cardiac ICUs: a multicentre cohort and survey study. [PDF]

Cardiol Young
Elgersma KM, Joy BF, Huang Z, Radman MR, Mills KI, Schramm JE, Wong JH, Chlebowski MM, Beshish AG, Safa R, Mueller D, Shutes BL, Flores S, Furlong-Dillard JM, Narasimhulu SS, Beach A, Goldstein S, Mendieta KS, Reddy R, Goldshtrom N, Schneider J, Liao G, Asfari A, Karki KB, Huibonhoa RMT, Mastropietro CW, Cashen K.   +26 more
europepmc   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Comparison of methods for defatted human milk and nutrient composition: An experimental study. [PDF]

JPEN J Parenter Enteral Nutr
Cheng K, O'Toole G, Chang S, Chang R, Miklavcic J.   +4 more
europepmc   +1 more source

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

Carbohydrate and Energy Composition of Preterm Human Milk: A Systematic Review and Meta-Analysis. [PDF]

Adv Nutr
Miketinas DC, Patterson MA, Thyne VK, Carter DL, Meredith NA, Nunez MF, Niemeier KE, Kinnaman JN, Bender TM, Bailey AD.   +9 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source