Results 51 to 60 of about 8,697,028 (307)

Human Milk Lipids [PDF]

Annals of Nutrition and Metabolism, 2016
Human milk lipids provide the infant with energy and essential vitamins, polyunsaturated fatty acids, and bioactive components. Adding complex lipids and milk fat globule membranes to vegetable oil-based infant formula has the potential to enhance infant development and reduce infections. Cholesterol provision with breastfeeding modulates infant sterol
openaire   +2 more sources

Time-dependent alterations of soluble and cellular components in human milk

, 2010
This study sought to determine the chronobiological variations in soluble and cellular components of human breast milk. The material was collected from 36 mothers at three stages of maturity - 3 days (colostrum), 10 days (transitional milk) and 30 days ...
Nicomedes, Tathianne dos Reis, Tathianne dos Reis Nicomedes, Iracema de Mattos Paranhos Calderon, Adenilda Cristina Honorio França, Eduardo Luzía França, Calderon, Iracema de Mattos Paranhos [UNESP], Franca, Eduardo Luzia, Honorio Franca, Adenilda Cristina, Calderon, Iracema de Mattos Paranhos   +8 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Receiving screened donor human milk as part of a community‐based lactation support programme reduces parental symptoms of anxiety and depression

Maternal and Child Nutrition
Infant feeding decisions and maternal mental health are closely tied. Donor human milk (DHM) protects premature infant health and development and can reduce hospital stays.
Amy Brown, Sam Griffin, Gillian Weaver, Natalie Shenker   +3 more
doaj   +1 more source

Enhanced versus standard fortification of pasteurized donor human milk for growth in very low birth weight infants: a randomized controlled trial

Frontiers in Nutrition
IntroductionVery-low-birthweight (VLBW) infants on pasteurized donor human milk (PDHM) have poorer growth compared to infants on fortified mother's milk, suggesting that standard fortification methods for PDHM are inadequate.MethodsWe designed a ...
Chengsi Ong, Anng Anng Wong, Siew Tin Wong, Ying Zheng, Cynthia Pui Chan Pang, Cynthia Pui Chan Pang, Pooja Agarwal Jayagobi, Pooja Agarwal Jayagobi, Joo Guan Yeo, Joo Guan Yeo, Joo Guan Yeo, Kee Thai Yeo, Kee Thai Yeo, Mei Chien Chua, Mei Chien Chua, Mei Chien Chua   +15 more
doaj   +1 more source

Establishing a novel community-focussed lactation support service: a descriptive case series

International Breastfeeding Journal, 2022
Background Although breastfeeding is widely acknowledged as protecting both infant and maternal health postnatally, a partial or complete shortfall of maternal milk can occur for a range of reasons.
Samantha Griffin, Jo Watt, Sophie Wedekind, Solange Bramer, Yasmin Hazemi-Jebelli, Robert Boyle, Gillian Weaver, Natalie S. Shenker   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Bovine milk with variant β-casein types on immunological mediated intestinal changes and gut health of mice

Frontiers in Nutrition, 2022
Dietary proteins provide bioactive peptides, which are important for host gastrointestinal functions. We hypothesized that A2-type β-casein could provide gastrointestinal benefits and improve the immune and gut health.
Bin Liu, Bin Liu, Weicang Qiao, Weicang Qiao, Minghui Zhang, Minghui Zhang, Yanpin Liu, Yanpin Liu, Junying Zhao, Junying Zhao, Lijun Chen, Lijun Chen   +11 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source