Results 81 to 90 of about 1,240,536 (340)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Milk is for Children, Colostrum silage is for calves. [PDF]

, 2011
One sixth of the world population is starving. In the meantime, producers from all over the world daily disdain billions of liters of bovine colostrum, which is seen as rich in nutrients, immunoglobulin and bioactive substances.
Daniela Brayer Pereira, Fá, Julia Valente, Kathleen Krü, Mara Helena Saalfeld, Marcia Gularte, Renata Schramm   +6 more
core   +1 more source

PCR Based Genotyping of Lulu Cattle of Nepal for A1, A2 Type Beta-caseins [PDF]

, 2020
Lulu is an indigenous breed of cattle (Bos taurus) found in high altitude regions of western Nepal. Population of Lulu cattle has been declining due to introgression with other exotic breeds to increase milk productivity.
Budhathoki, N. (Nabina), GC, S. (Sudarshan), Gorkhali, N. A. (Neena), Lama, S. (Srijana), Pokharel, P. (Prashanna), Pokhrel, B. R. (Bhoj), Sapkota, S. (Saroj), Sherpa, C. (Chhiring)   +7 more
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Diversity of Human Milk Oligosaccharides and Effects on Early Life Immune Development

Frontiers in Pediatrics, 2018
One of the well-known features of human milk, is the capacity to protect against the risk and impact of neonatal infections, as well as to influence the onset of allergic and metabolic disease manifestations.
Veronica Ayechu-Muruzabal, Arthur H. van Stigt, Marko Mank, Linette E. M. Willemsen, Bernd Stahl, Johan Garssen, Johan Garssen, Belinda van't Land, Belinda van't Land   +8 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Modulating the developing gut microbiota with 2’-fucosyllactose and pooled human milk oligosaccharides

Microbiome
Background Synthetic human milk oligosaccharides (HMOs) are used to supplement infant formula despite limited understanding of their impact on the post-weaned developing gut microbiota. Here, we assess the influence of 0.5 g/L 2-fucosyllactose (2’FL) and
Simone Renwick, Annalee Furst, Mikael Knip, on behalf of the DIABIMMUNE Study Group, Lars Bode, Jayne S. Danska, Emma Allen-Vercoe   +6 more
doaj   +1 more source

Research Progress of Sensors Technology Based on DNA Walker in Food Safety Detection

Shipin gongye ke-ji
With the rapid development of DNA nanotechnology, DNA molecules with various structures and functions are used to construct programmable nanomachines with dynamic behaviors.
Siqing SONG, Xiaoxia SI, Jufeng HU, Zimo DU, Lijun CHEN, Jichao LIU   +5 more
doaj   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

Donation barriers, enablers, patterns and predictors of milk bank donors in the United States and United Kingdom

Maternal and Child Nutrition
Pasteurised donor human milk is recommended for very low birthweight infants who do not have access to their mother's milk. Although the use of donor milk continues to increase, little is known about the donation experiences of milk bank donors. We aimed
Bruna Gutierrez dosSantos, Natalie Shenker, Gillian Weaver, Maryanne T. Perrin   +3 more
doaj   +1 more source