Results 51 to 60 of about 31,439 (263)

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Determination Methods of Food Fibers Characteristics in Milk Mixtures with the Modified Fat Composition [PDF]

, 2019
The article presents main determination methods of technological parameters of food fibers in milk mixtures of the modified fat composition.The methods of studying the ability of food fibers to water and fat-absorption are offered.
Grek, O. (Olena), Ochkolyas, О. (Оlena), Ovsiienko, K. (Kіra), Savchenko, O. (Oleksandr), Tsygankov, S. (Sergii), Tymchuk, A. (Alla)   +5 more
core  

Energy embodied in household cookery: the missing part of a sustainable food system? Part 1: A method to survey and calculate representative recipes [PDF]

, 2017
This paper firstly reviews the current state of knowledge on sustainable cookery and the environmental impacts of the food consumption phase. It then uses the example of a dish of roast beef and Yorkshire pudding to explore energy use in food production ...
Bajželj, Baldwin, Bryngelsson, Christian J. Reynolds, COLLISON, Davis, Davis, Defra, DeMerchant, Freidberg, Garnett, Haines, Hunt, John Reynolds, Macdiarmid, Mansouri, May, Monteiro, Muñoz, Newborough, Pathak, Reynolds, Rivera, Rivera, Scarborough, Sonesson, Springmann, Toon, Wheeler, Wood, Woods, Yao   +31 more
core   +2 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

酶法富集甘油酯型n-3 PUFA的研究进展Research progress on enzymatic enrichment of glyceride-type n-3 PUFA

Zhongguo youzhi
n-3多不饱和脂肪酸（n-3 PUFA）是人体生长和健康不可或缺的一类脂肪酸。然而，天然甘油酯中的n-3 PUFA含量较低，限制了其利用价值。随着食品、医药、母乳脂替代和保健品等行业对高含量n-3 PUFA需求的不断增长，富集n-3 PUFA甘油酯已成为研究热点。其中，酶法富集因高效、绿色环保等优势，受到研究者的青睐。旨在为绿色高效酶法富集甘油酯型n-3 PUFA的研究与应用提供理论指导，综述了酶法富集n-3 PUFA甘油酯中脂肪酶的筛选、酶法富集技术路线和反应体系优化的研究进展。酶法富集n-3 ...
吴留美1,2，张羽飞2，梁永霞1，郑明明1,2，黎冬明1 WU Liumei1,2, ZHANG Yufei2, LIANG Yongxia1, ZHENG Mingming1,2, LI Dongming1
doaj   +1 more source

Development of free sugar white chocolate, suitable for diabetics, using Stevia and sucralose as sweeteners: study of the thermal degradation kinetic [PDF]

, 2016
The purpose of this study was the development of formulations of white chocolate for diabetics with replacement of sucrose by sucralose (Su) and Stevia (St) using a mixture experimental design.
Baracco, Yanina Andrea, Campderrós, Mercedes Edith, Rodriguez Furlán, Laura Teresa, Zaritzky, Noemi Elisabet   +3 more
core   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Tackling the Global NCD Crisis: Innovations in Law and Governance [PDF]

, 2013
35 million people die annually of non-communicable diseases (NCDs), 80% of them in low- and middle-income countries—representing a marked epidemiological transition from infectious to chronic diseases and from richer to poorer countries. The total number
Gostin, Lawrence O., Thomas, Bryan P.
core   +3 more sources