Results 111 to 120 of about 3,598,736 (304)

A transparent four-feature speech model for depression screening applicable across clinical and community settings, including assisted-living environments

Frontiers in Digital Health
Depression in older adults, often underrecognized and frequently conflated with cognitive symptoms, remains a major challenge in settings such as assisted-living communities.
Kevin Mekulu, Faisal Aqlan, Hui Yang
doaj   +1 more source

Global versus local managing human resources in the multinational company [PDF]

, 1996
This paper considers the extent to which multinational enterprises adopt a global or local approach in their management of human resources. Nine organisations, drawn from a range of nationalities and sectors operating in Ireland, were examined.
Monks, Kathy
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Proof-of-concept model for instantaneous heart rate-drift correction during low and high exercise exertion

Frontiers in Physiology
Introduction: This study aimed to model below and above anaerobic threshold exercise-induced heart rate (HR) drift, so that the corrected HR could better represent V̇O2 kinetics during and after the exercise itself.Methods: Fifteen healthy subjects (age:
Gabriele B. Papini, Gabriele B. Papini, Alberto G. Bonomi, Francesco Sartor, Francesco Sartor   +4 more
doaj   +1 more source

Display/control requirements for VTOL aircraft [PDF]

Quantative metrics were determined for system control performance, workload for control, monitoring performance, and workload for monitoring. Pilot tasks were allocated for navigation and guidance of automated commercial V/STOL aircraft in all weather ...
Curry, R. E., Hoffman, W. C., Hollister, W. M., Kleinman, D. L., Young, L. R.   +4 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

CharMark: character-level Markov modeling for interpretable linguistic biomarkers of cognitive decline

Frontiers in Digital Health
Dementia, one of the most prevalent neurodegenerative diseases, affects millions worldwide. Understanding linguistic markers of dementia is crucial for elucidating how cognitive decline manifests in speech patterns.
Kevin Mekulu, Faisal Aqlan, Hui Yang
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Highly Sensitive E-Textile Strain Sensors Enhanced by Geometrical Treatment for Human Monitoring. [PDF]

Sensors (Basel), 2020
Vu CC, Kim J.
europepmc   +1 more source

Detecting Irregular Patterns in IoT Streaming Data for Fall Detection

, 2018
Detecting patterns in real time streaming data has been an interesting and challenging data analytics problem. With the proliferation of a variety of sensor devices, real-time analytics of data from the Internet of Things (IoT) to learn regular and ...
Isah, Haruna, Mahfuz, Sazia, Nicholls, Peter, Zulkernine, Farhana   +3 more
core   +1 more source