Results 131 to 140 of about 10,737,457 (301)
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.Based on data from 3259 women, this study identified older age, history of hysterectomy, specific HPV genotypes, abnormal cytology, and concurrent cervical/vulvar lesions as independent risk factors for VaIN2+ and incorporated them into a nomogram. This nomogram provides individualized VaIN2+ risk assessment to facilitate proactive identification of ...
Quanlong Lu +8 more
wiley +1 more source
Preventing Human Papillomavirus and Vaccine Strategies
VaccinesVaccination against human papillomavirus (HPV) has been widely adopted, aiming at preventing infection and, ultimately, the development of HPV-driven uterine cervical neoplasia [...]
Rui M. Gil da Costa
doaj +1 more source
Longitudinal methylation analysis for risk stratification of CIN2 lesions by HPV genotype
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.The S5 classifier demonstrates promising utility for predicting CIN2 progression, including in non‐HPV16/18 infections. Its predictive lead time may support risk‐stratified active surveillance, helping reduce overtreatment and associated obstetric complications while ensuring timely management of progressive disease.
Hanna Pikkujämsä +9 more
wiley +1 more source
BJU International, EarlyView.Objectives To determine the prevalence of programmed death ligand 1 (PD‐L1) expression in penile squamous cell carcinoma (PSCC) and evaluate its associations with clinicopathological features and survival outcomes. Patients and Methods A systematic review was carried out using PubMed, the Excerpta Medica dataBASE (EMBASE), Scopus, Web of Science and ...
Diarmuid D. Sugrue +5 more
wiley +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Immunology of Papillomavirus Infection of the Human Anogenital Epithelium
, 1990 This article reviews the immunobiology of human papillomavirus (HPV) infection with special reference to HPV-associated lesions of the female genital ...
Park, D. +5 more
core +1 more source
Cancer Science, EarlyView.Fractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Na‐Eun Kang +5 more
wiley +1 more source
Where is the Human Papillomavirus vaccine heading? A Review
Journal of Contemporary MedicineDNA oncogenic viruses include Human papillomavirus that causes epithelial proliferation at cutaneous and mucosal surfaces. Human papillomavirus is the most common sexually transmitted infection.
Burcu Parlak
doaj
Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria
Cancer Science, EarlyView.Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren +11 more
wiley +1 more source
Dioscin Promotes Ferroptosis in Cervical Cancer Cells via the TIGAR‐ROS Axis
Cancer Science, EarlyView.Dioscin suppresses cervical cancer progression by promoting ferroptosis. Mechanistically, Dioscin binds to TIGAR and inhibits TIGAR function, elevating ROS levels and inducing ferroptosis. ABSTRACT Cervical cancer seriously threatens women's life and health, highlighting the urgent need for targeted therapies.
Yameng Liu +6 more
wiley +1 more source