PD-L1 is an intrinsic switch for natural killer cell-mediated, TRAIL-dependent antiviral function
Cell ReportsSummary: Each year, influenza A virus (IAV) infection of the lung causes half a million deaths worldwide. Patients with compromised immunity experience distinct influenza pathogenesis; however, most IAV-related research is done with wild-type mice or ...
Kayla Frank +9 more
doaj +1 more source
Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. [PDF]
, 2007 We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions ...
Au, T +5 more
core
A Viral Protein Antagonist for Both AID and APOBEC3
VirusesThe APOBEC family of cytidine deaminases is part of the innate immune response to infections by multiple RNA- and DNA-containing viruses. Since the activity of these enzymes, typically APOBEC3, often involves mutations that inhibit or block viral ...
Jaquelin P. Dudley
doaj +1 more source
Last Year\u27s Virus, This Year\u27s Cancer Treatment [PDF]
, 2018 For hundreds of years, cancer has stumped medical professionals across the world as a cure evaded them. Now, a new approach to battling cancer has entered the arena: viruses.
Collins, Olivia
core +1 more source
Cervical cancer with Human Papilloma Virus and Epstein Barr Virus positive [PDF]
, 2006 The Early-7 (E7) protein of HPV binds to the underphosphorelated form of the tumor suppressor protein – pRb and displaces the E2F transcription factor that is normally bound by pRb.
Prayitno, Adi
core +1 more source
Epstein-Barr virus, infectious mononucleosis, and posttransplant lymphoproliferative disorders. [PDF]
, 1994 PTLD may be considered as an "opportunistic cancer" in which the immunodeficiency state of the host plays a key role in fostering the environment necessary for abnormal lymphoproliferation.
Nalesnik, MA, Starzl, TE
core
PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
Advanced ScienceThe efficacy of immunotherapy in enhancing antitumor immunity in solid tumors remains limited, primarily due to the insufficient immunogenicity of tumor cells.
Huixin Gao +24 more
doaj +1 more source
The interplay between viral-derived miRNAs and host immunity during infection [PDF]
, 2019 MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection.
Ingle, Harshad +3 more
core +1 more source
Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs [PDF]
, 2014 The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions.
Manjili, Masoud H.
core +1 more source
Leveraging oncovirus-derived antigen against the viral malignancies in adoptive cell therapies
Biomarker ResearchAdoptive cell therapies (ACTs) have revolutionized cancer immunotherapy, prompting exploration into their application against oncoviruses. Oncoviruses such as human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Epstein-Barr ...
Wei Zhang, Miao Zeng, Yisheng Li, Li Yu
doaj +1 more source