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The Viral Origin of Human Breast Cancer: From the Mouse Mammary Tumor Virus (MMTV) to the Human Betaretrovirus (HBRV)

Viruses, 2022
A Human Betaretrovirus (HBRV) has been identified in humans, dating as far back as about 4500 years ago, with a high probability of it being acquired by our species around 10,000 years ago, following a species jump from mice to humans.
Generoso Bevilacqua
doaj   +4 more sources

Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue

Viruses, 2022
Since its discovery as a milk factor, mouse mammary tumor virus (MMTV) has been shown to cause mammary carcinoma and lymphoma in mice. MMTV infection depends upon a viral superantigen (sag)-induced immune response and exploits the immune system to ...
Francesca Parisi, Giulia Freer, Chiara Maria Mazzanti, Mauro Pistello, Alessandro Poli   +4 more
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Association of Mouse Mammary Tumor Virus With Human Breast Cancer: Histology, Immunohistochemistry and Polymerase Chain Reaction Analyses

Frontiers in Oncology, 2018
PurposeThe purpose of this study is to determine whether mouse mammary tumor virus (MMTV)-associated human breast cancer has the same or similar histology to MMTV-associated mouse mammary tumors.
James S. Lawson, Chiara Mazzanti, Prospero Civita, Michele Menicagli, Christopher C. Ngan, Noel J. Whitaker, Jacob Hochman, Ori Braitbard, Benafsha Yosufi, Wendy K. Glenn   +9 more
doaj   +2 more sources

Human Mammary Tumor Virus, Human Papilloma Virus, and Epstein-Barr Virus Infection Are Associated With Sporadic Breast Cancer Metastasis

Breast Cancer: Basic and Clinical Research, 2020
Background: Viral cause of sporadic breast cancer (SBC) has been suggested based on the experimental murine model of mammary tumor caused by mouse mammary tumor virus (MMTV), Epstein-Barr virus (EBV), and human papillomavirus (HPV).
Mohammad Al Hamad, Ismail Matalka, Mazhar Salim Al Zoubi, Ivana Armogida, Rawan Khasawneh, Maysa Al-Husaini, Maher Sughayer, Saied Jaradat, Amjad D Al-Nasser, Chiara Maria Mazzanti   +9 more
doaj   +2 more sources

Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect [PDF]

BMC Biology
Background Tumor-associated architecture and emerging mechanical properties (forces, pressure, tension, stiffness) affect the growth and invasiveness of cancer cells.
Lisbeth Berrueta, Chandra Bhan, Yi He, Rebecca D. Thompson, Oscar Safairad, Andrew D. Doyle, Paola Pérez, Daniel Martin, Mazen Mezher, Alexander Cartagena-Rivera, Gary J. Badger, Helene M. Langevin   +11 more
doaj   +2 more sources

Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo

Retrovirology, 2012
Background Bone marrow stromal cell antigen 2 (BST-2) is a cellular factor that restricts the egress of viruses such as human immunodeficiency virus (HIV-1) from the surface of infected cells, preventing infection of new cells.
Jones Philip H, Mehta Harshini V, Maric Martina, Roller Richard J, Okeoma Chioma M   +4 more
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Human betaretrovirus (HBRV), homologous to mouse mammary tumor virus (MMTV), and human breast cancer: a significant epidemiological association [PDF]

Retrovirology
Background Breast cancer is the most commonly diagnosed cancer globally. The potential role of oncogenic viruses, particularly Human Betaretrovirus (HBRV, formerly MMTV-LV/HMTV), in the pathogenesis of breast cancer has been a subject of research for ...
Fateme Saeedi-Moghaddam, Nazila Saffarian, Sayed-Hamidreza Mozhgani   +2 more
doaj   +2 more sources

Therapy of 4T1 breast cancer in mice with Vaccinia virus encoding tumor-associated antigen epitopes and mouse IL2 cytokine [PDF]

Frontiers in Immunology
IntroductionOncolytic vaccinia virus (VACV) strains are being investigated for use in immunotherapy as a new experimental cancer treatment. Here, we describe the construction, characterization, and use of VACV strains co-expressing murine Interleukin 2 ...
Mingyu Ye, Ivan Petrov, Ivaylo Gentschev, Eman M. Othman, Aladar A. Szalay, Aladar A. Szalay, Aladar A. Szalay   +6 more
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A Viral Protein Antagonist for Both AID and APOBEC3 [PDF]

Viruses
The APOBEC family of cytidine deaminases is part of the innate immune response to infections by multiple RNA- and DNA-containing viruses. Since the activity of these enzymes, typically APOBEC3, often involves mutations that inhibit or block viral ...
Jaquelin P. Dudley
doaj   +2 more sources

In Vitro System for Production of Mouse Mammary Tumor Virus [PDF]

Applied Microbiology, 1974
An in vitro system for production, purification, and concentration of mouse mammary tumor virus is described. Monolayer cultures of C 3 H mouse mammary tumor cells propagated at 34 C in roller bottles in the presence of dexamethasone, a glucocorticoid hormone, release B-type particles which ...
D L, Fine, L O, Arthur, J K, PLOWMAN, E A, Hillman, F, Klein   +4 more
openaire   +3 more sources