Results 21 to 30 of about 88,076 (273)

Merlin deficiency alters the redox management program in breast cancer

Molecular Oncology, 2021
The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues.
Mateus Mota, Brandon J. Metge, Dominique C. Hinshaw, Heba A. Alsheikh, Dongquan Chen, Rajeev S. Samant, Lalita A. Shevde   +6 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype. [PDF]

PLoS ONE, 2014
Mammary epithelial (ME) cells cultured under conventional conditions senesce after several passages. Here, we demonstrate that mouse ME cells isolated from normal mammary glands or from mouse mammary tumor virus (MMTV)-Neu-induced mammary tumors, can be ...
Francisco R Saenz, Virginie Ory, Maram AlOtaiby, Sonia Rosenfield, Mary Furlong, Luciane R Cavalli, Michael D Johnson, Xuefeng Liu, Richard Schlegel, Anton Wellstein, Anna T Riegel   +10 more
doaj   +1 more source

Conversion of Mouse Mammary Tumor Virus to a Lymphomagenic Virus [PDF]

Journal of Virology, 2005
ABSTRACT Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of ...
Sanchita, Bhadra, Mary M, Lozano, Jaquelin P, Dudley   +2 more
openaire   +2 more sources

Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. [PDF]

PLoS ONE, 2012
We have generated a new and improved transgenic mouse strain that permits a temporally controlled expression of transgenes throughout mammary gland development.
Kazuhito Sakamoto, Jeffrey W Schmidt, Kay-Uwe Wagner   +2 more
doaj   +1 more source

Multi-color Flow Cytometry for Comprehensive Analysis of the Tumor Immune Infiltrate in a Murine Model of Breast Cancer

Bio-Protocol, 2021
Flow cytometry is a popular laser-based technology that allows the phenotypic and functional characterization of individual cells in a high-throughput manner.
Ana Almeida, Miriam Fein, Mikala Egeblad
doaj   +1 more source

Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages [PDF]

, 2007
Genetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy.
Pollard, Jeffrey W, Bricard, Gabriel, Wang, Weigang, Deng, Yan, Porcelli, Steven A, Sellers, Rani, Lin, Elaine Y, Li, Jiu-feng   +7 more
core   +1 more source

Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar

Infectious Agents and Cancer, 2017
Background Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors.
Thar Htet San, Masayoshi Fujisawa, Soichiro Fushimi, Teizo Yoshimura, Toshiaki Ohara, Lamin Soe, Ngu Wah Min, Ohnmar Kyaw, Xu Yang, Akihiro Matsukawa   +9 more
doaj   +1 more source

Effect of trypsin on mouse mammary tumor virus [PDF]

Journal of Virology, 1976
Undisrupted mouse mammary tumor virus (MuMTV) derived from the milk of of RIII mice has been analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electron microscopy after treatment with insolubilized trypsin. No alterations were found in viral fine structure by either freeze-etch or negative-stain electron microscopy.
Sheffield, J B, Zacharchuk, C M, Taraschi, N, Daly, T M   +3 more
openaire   +2 more sources

Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV)

Frontiers in Oncology, 2018
Background Although the risk factors for breast cancer are well established, namely female gender, early menarche and late menopause plus the protective influence of early pregnancy, the underlying causes of breast cancer remain unknown.
J. Lawson, Brian Salmons, W. Glenn
semanticscholar   +1 more source