Results 21 to 30 of about 61,923 (187)
Decitabine suppresses tumor growth by activating mouse mammary tumor virus and interferon-β pathways [PDF]
Biomolecules & BiomedicineDecitabine (DAC), a DNA methyltransferase inhibitor (DNMTi), is clinically effective in hematological malignancies such as myelodysplastic syndrome and acute myeloid leukemia, but its precise antineoplastic mechanisms remain incompletely understood ...
Ryan Johnson +9 more
doaj +2 more sources
Characterization of Mammary Tumors Arising from MMTV-PyVT Transgenic Mice
Current Issues in Molecular Biology, 2023 Among genetically engineered mouse models of breast cancer, MMTV-PyVT is a mouse strain in which the oncogenic polyoma virus middle T antigen is driven by the mouse mammary tumor virus promoter. The aim of the present study was to perform morphologic and
Chien-Liang Liu +6 more
doaj +1 more source
Special Issue “Human Betaretrovirus and Related Diseases”
Viruses, 2022 A betaretrovirus resembling mouse mammary tumor virus (MMTV) was first linked with human breast cancer over 50 years ago [...]
Andrew L. Mason
doaj +1 more source
Cryoelectron Microscopy of Mouse Mammary Tumor Virus [PDF]
Journal of Virology, 2004 ABSTRACT Cryoelectron microscopy of Mouse mammary tumor virus , a Betaretrovirus , provided information about glycoprotein structure and core formation. The virions showed the broad range of diameters typical of retroviruses.
Briggs, J. +3 more
openaire +3 more sources
Merlin deficiency alters the redox management program in breast cancer
Molecular Oncology, 2021 The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues.
Mateus Mota +6 more
doaj +1 more source
Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype. [PDF]
PLoS ONE, 2014 Mammary epithelial (ME) cells cultured under conventional conditions senesce after several passages. Here, we demonstrate that mouse ME cells isolated from normal mammary glands or from mouse mammary tumor virus (MMTV)-Neu-induced mammary tumors, can be ...
Francisco R Saenz +10 more
doaj +1 more source
Conversion of Mouse Mammary Tumor Virus to a Lymphomagenic Virus [PDF]
Journal of Virology, 2005 ABSTRACT Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of ...
Sanchita, Bhadra +2 more
openaire +2 more sources
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. [PDF]
PLoS ONE, 2012 We have generated a new and improved transgenic mouse strain that permits a temporally controlled expression of transgenes throughout mammary gland development.
Kazuhito Sakamoto +2 more
doaj +1 more source
Bio-Protocol, 2021 Flow cytometry is a popular laser-based technology that allows the phenotypic and functional characterization of individual cells in a high-throughput manner.
Ana Almeida, Miriam Fein, Mikala Egeblad
doaj +1 more source