Results 11 to 20 of about 61,923 (187)

Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue

Viruses, 2022
Since its discovery as a milk factor, mouse mammary tumor virus (MMTV) has been shown to cause mammary carcinoma and lymphoma in mice. MMTV infection depends upon a viral superantigen (sag)-induced immune response and exploits the immune system to ...
Francesca Parisi, Giulia Freer, Chiara Maria Mazzanti, Mauro Pistello, Alessandro Poli   +4 more
doaj   +3 more sources

The Viral Origin of Human Breast Cancer: From the Mouse Mammary Tumor Virus (MMTV) to the Human Betaretrovirus (HBRV)

Viruses, 2022
A Human Betaretrovirus (HBRV) has been identified in humans, dating as far back as about 4500 years ago, with a high probability of it being acquired by our species around 10,000 years ago, following a species jump from mice to humans.
Generoso Bevilacqua
doaj   +3 more sources

Global Down-regulation of Gene Expression Induced by Mouse Mammary Tumor Virus (MMTV) in Normal Mammary Epithelial Cells

Viruses, 2023
Mouse mammary tumor virus (MMTV) is a betaretrovirus that causes breast cancer in mice. The mouse mammary epithelial cells are the most permissive cells for MMTV, expressing the highest levels of virus upon infection and being the ones later transformed ...
Waqar Ahmad, Neena G. Panicker, Shaima Akhlaq, Bushra Gull, Jasmin Baby, Thanumol A. Khader, Tahir A. Rizvi, Farah Mustafa   +7 more
doaj   +3 more sources

Association of Mouse Mammary Tumor Virus With Human Breast Cancer: Histology, Immunohistochemistry and Polymerase Chain Reaction Analyses

Frontiers in Oncology, 2018
PurposeThe purpose of this study is to determine whether mouse mammary tumor virus (MMTV)-associated human breast cancer has the same or similar histology to MMTV-associated mouse mammary tumors.
James S. Lawson, Chiara Mazzanti, Prospero Civita, Michele Menicagli, Christopher C. Ngan, Noel J. Whitaker, Jacob Hochman, Ori Braitbard, Benafsha Yosufi, Wendy K. Glenn   +9 more
doaj   +3 more sources

Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect [PDF]

BMC Biology
Background Tumor-associated architecture and emerging mechanical properties (forces, pressure, tension, stiffness) affect the growth and invasiveness of cancer cells.
Lisbeth Berrueta, Chandra Bhan, Yi He, Rebecca D. Thompson, Oscar Safairad, Andrew D. Doyle, Paola Pérez, Daniel Martin, Mazen Mezher, Alexander Cartagena-Rivera, Gary J. Badger, Helene M. Langevin   +11 more
doaj   +2 more sources

Human betaretrovirus (HBRV), homologous to mouse mammary tumor virus (MMTV), and human breast cancer: a significant epidemiological association [PDF]

Retrovirology
Background Breast cancer is the most commonly diagnosed cancer globally. The potential role of oncogenic viruses, particularly Human Betaretrovirus (HBRV, formerly MMTV-LV/HMTV), in the pathogenesis of breast cancer has been a subject of research for ...
Fateme Saeedi-Moghaddam, Nazila Saffarian, Sayed-Hamidreza Mozhgani   +2 more
doaj   +2 more sources

Intestinal Immune System and Amplification of Mouse Mammary Tumor Virus

Frontiers in Cellular and Infection Microbiology, 2022
Mouse mammary tumor virus (MMTV) is a virus that induces breast cancer in mice. During lactation, MMTV can transmit from mother to offspring through milk, and Peyer’s patches (PPs) in mouse intestine are the first and specific target organ.
Lankai Chen, Xipeng Zhang, Guisheng Liu, Shuo Chen, Minying Zheng, Siwei Zhu, Shiwu Zhang   +6 more
doaj   +3 more sources

A Viral Protein Antagonist for Both AID and APOBEC3 [PDF]

Viruses
The APOBEC family of cytidine deaminases is part of the innate immune response to infections by multiple RNA- and DNA-containing viruses. Since the activity of these enzymes, typically APOBEC3, often involves mutations that inhibit or block viral ...
Jaquelin P. Dudley
doaj   +2 more sources

Therapy of 4T1 breast cancer in mice with Vaccinia virus encoding tumor-associated antigen epitopes and mouse IL2 cytokine [PDF]

Frontiers in Immunology
IntroductionOncolytic vaccinia virus (VACV) strains are being investigated for use in immunotherapy as a new experimental cancer treatment. Here, we describe the construction, characterization, and use of VACV strains co-expressing murine Interleukin 2 ...
Mingyu Ye, Ivan Petrov, Ivaylo Gentschev, Eman M. Othman, Aladar A. Szalay, Aladar A. Szalay, Aladar A. Szalay   +6 more
doaj   +2 more sources

IFI16/IFI202 blockade suppresses tumor growth through CD8+ T-cell–mediated immunity [PDF]

Breast Cancer Research
Background Tumor-associated macrophages (TAMs) are key drivers of immunosuppressive inflammation in the breast cancer microenvironment, promoting tumor progression and resistance to immune checkpoint blockade.
Ga Young Lim, Na-Lee Ka, Seung-Su Kim, Mi-Ock Lee   +3 more
doaj   +2 more sources