Results 1 to 10 of about 63,529 (225)
Rapid spread of mouse mammary tumor virus in cultured human breast cells
Retrovirology, 2007 Background The role of mouse mammary tumor virus (MMTV) as a causative agent in human breast carcinogenesis has recently been the subject of renewed interest.
Günzburg Walter H +4 more
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Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype. [PDF]
PLoS ONE, 2014 Mammary epithelial (ME) cells cultured under conventional conditions senesce after several passages. Here, we demonstrate that mouse ME cells isolated from normal mammary glands or from mouse mammary tumor virus (MMTV)-Neu-induced mammary tumors, can be ...
Francisco R Saenz +10 more
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Conversion of Mouse Mammary Tumor Virus to a Lymphomagenic Virus [PDF]
Journal of Virology, 2005 ABSTRACT Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of ...
Sanchita, Bhadra +2 more
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Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. [PDF]
PLoS ONE, 2012 We have generated a new and improved transgenic mouse strain that permits a temporally controlled expression of transgenes throughout mammary gland development.
Kazuhito Sakamoto +2 more
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Bio-Protocol, 2021 Flow cytometry is a popular laser-based technology that allows the phenotypic and functional characterization of individual cells in a high-throughput manner.
Ana Almeida, Miriam Fein, Mikala Egeblad
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Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar
Infectious Agents and Cancer, 2017 Background Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors.
Thar Htet San +9 more
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Effect of trypsin on mouse mammary tumor virus [PDF]
Journal of Virology, 1976 Undisrupted mouse mammary tumor virus (MuMTV) derived from the milk of of RIII mice has been analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electron microscopy after treatment with insolubilized trypsin. No alterations were found in viral fine structure by either freeze-etch or negative-stain electron microscopy.
Sheffield, J B +3 more
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Apc mutation enhances PyMT-induced mammary tumorigenesis.
PLoS ONE, 2011 The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation ...
Jenifer R Prosperi +3 more
doaj +1 more source
Cells, 2013 Tumorigenesis is often described as a result of accumulated mutations that lead to growth advantage and clonal expansion of mutated cells. There is evidence in the literature that cancer cells are influenced by the microenvironment.
Sonia M. Rosenfield, Gilbert H. Smith
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In Vitro Production of Mouse Mammary Tumor Virus in a Mouse Mammary Tumor Ascites Line [PDF]
Proceedings of the National Academy of Sciences, 1973 An ascites line derived from a spontaneous mouse mammary carcinoma produces, on explantation and cultivation in vitro , large amounts of oncornavirus particles. The biochemical, biophysical, and electron microscopic characteristics of the virions are described.
Keydar, J +3 more
openaire +2 more sources