Results 41 to 50 of about 63,529 (225)

The Role of a Betaretrovirus in Human Breast Cancer: Enveloping a Conundrum

Viruses, 2022
Most of the evidence that a human betaretrovirus (HBRV/HMTV) highly related to mouse mammary tumour virus (MMTV) has an etiological role in breast cancer has been summarized in a recent comprehensive Special Issue of “Viruses” entitled “Human ...
Walter H. Gunzburg, Brian Salmons
doaj   +1 more source

PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development.

PLoS ONE, 2017
CD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer, including breast cancer.
Robin M H Rumney, Seth B Coffelt, Terence A Neale, Sandeep Dhayade, Gillian M Tozer, Gaynor Miller   +5 more
doaj   +1 more source

Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen. [PDF]

, 2012
A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor ...
Georg Enders (187983), Vetter Elena Viviana, Schultze, Joachim L., Elena Viviana Vetter (187975), Wolfgang Zimmermann, Elena Viviana Vetter, Pan Jie, Joachim L. Schultze, Zimmermann Wolfgang, Ihler, Fritz, Jie Pan, Joachim L Schultze, Debey-Pascher Svenja, Schultze Joachim L., Enders, Georg, Pan, Jie, Kammerer Robert, Zimmermann, Wolfgang, Svenja Debey-Pascher (187980), Wolfgang Zimmermann (1543), Vetter, Elena Viviana, Georg Enders, Robert Kammerer, Kammerer, Robert, Robert Kammerer (72621), Enders Georg, Ihler Fritz, Joachim L. Schultze (133356), Debey-Pascher, Svenja, Jie Pan (187977), Fritz Ihler (187972), Fritz Ihler, Svenja Debey-Pascher   +32 more
core   +1 more source

Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models

The Journal of Clinical Investigation, 2023
The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen XVIII (ColXVIII) is induced in solid tumors, but its involvement in tumorigenesis has remained ...
Raman Devarajan, Valerio Izzi, Hellevi Peltoketo, Gunilla Rask, Saila Kauppila, Marja-Riitta Väisänen, Heli Ruotsalainen, Guillermo Martínez-Nieto, Sanna-Maria Karppinen, Timo Väisänen, Inderjeet Kaur, Jussi Koivunen, Takako Sasaki, Robert Winqvist, Aki Manninen, Fredrik Wärnberg, Malin Sund, Taina Pihlajaniemi, Ritva Heljasvaara   +18 more
doaj   +1 more source

Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

Cell Reports, 2021
Summary: Basal breast cancer is associated with younger age, early relapse, and a high mortality rate. Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate the cellular basis of tumor progression during the specification ...
Fátima Valdés-Mora, Robert Salomon, Brian Stewart Gloss, Andrew Man Kit Law, Jeron Venhuizen, Lesley Castillo, Kendelle Joan Murphy, Astrid Magenau, Michael Papanicolaou, Laura Rodriguez de la Fuente, Daniel Lee Roden, Yolanda Colino-Sanguino, Zoya Kikhtyak, Nona Farbehi, James Ronald William Conway, Neblina Sikta, Samantha Richelle Oakes, Thomas Robert Cox, Seán Ignatius O’Donoghue, Paul Timpson, Christopher John Ormandy, David Gallego-Ortega   +21 more
doaj   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Expression of Mouse Mammary Tumor Virus Envelope Protein Does Not Prevent Superinfection In Vivo or In Vitro

, 1999
Inbred mice expressing endogenous mouse mammary tumor virus envelope proteins can be infected with exogenous virus, and the mammary tumors that develop in these mice usually have many proviruses integrated in their genomes, indicating that this virus is ...
Denis Kapkov, Tatyana V. Golovkina, Ross, S R, Dzuris, John L., Wei Zhu, Kapkov, Denis, Susan R. Ross, Zhu, Wei, Golovkina, Tatyana V., John L. Dzuris, Dzuris, J L, Golovkina, T V, Kapkov, D, Ross, Susan R., Zhu, W   +14 more
core   +1 more source

Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation

FEBS Open Bio, 2018
Mammalian eukaryotic translation initiation factor 3 (eIF3) is the largest complex of the translation initiation factors. The eIF3 complex is comprised of thirteen subunits, which are named eIF3a to eIF3 m in most multicellular organisms.
Daichi Sadato, Tomio Ono, Saki Gotoh‐Saito, Naoki Kajiwara, Namiko Nomura, Masako Ukaji, Liying Yang, Kenji Sakimura, Youichi Tajima, Keisuke Oboki, Futoshi Shibasaki   +10 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source