Macroscopic changes in the mammary glands of healthy cats after progestogen administration
Semina: Ciências Agrárias, 2023 The administration of contraceptives in female cats leads to problems such as pyometra, fetal maceration, mammary hyperplasia, and mammary neoplasms.
Maisa Martins Quirilos Assis +7 more
doaj +3 more sources
Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression
Cell Reports, 2018 Summary: Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signaling, tissue homeostasis, and cancer development. Using a breast cancer model that conditionally lacks Janus kinase 1, we show here that JAK1 is essential ...
Barbara L. Wehde +5 more
doaj +2 more sources
Canine, Feline, and Murine Mammary Tumors as a Model for Translational Research in Breast Cancer
Veterinary SciencesIn veterinary medicine, mammary tumors are the most common neoplasms in female dogs and the third most frequent in cats, representing a significant challenge.
Geovanni Dantas Cassali +10 more
doaj +2 more sources
Rat mammary carcinogenesis following neutron- or X-radiation [PDF]
, 1974 Female 61 to 63 - day - old Sprague-Dawley rats were exposed once to a single dose of either 0.43 - MeV neutrons or 250 - kVX - rays . For neutrons 23 rats were exposed in plastic tubes rotated around and 31 c m from a water-cooled tritium impregnated ...
Rossi, H. H. +8 more
core +1 more source
Mathematical methods and models for radiation carcinogenesis studies [PDF]
, 1986 Research on radiation carcinogenesis requires a twofold approach. Studies of primary molecular lesions and subsequent cytogenetic changes are essential, but they cannot at present provide numerical estimates of the risk of small doses of ionizing ...
Kellerer, Albrecht M.
core +1 more source
Modeling Diet-Induced Obesity with Obesity-Prone Rats: Implications for Studies in Females.
Frontiers in Nutrition, 2016 Obesity is a worldwide epidemic, and the comorbidities associated with obesity are numerous. Over the last two decades, we and others have employed an outbred rat model to study the development and persistence of obesity, as well as the metabolic ...
Erin D Giles +2 more
doaj +1 more source
Sonodynamic and sono-photodynamic therapy in oncology
Biomedical Photonics, 2019 In the present publication, authors have analyzed the results of using sonodynamic and sono-photodynamic therapy with photosensitizing agents of various classes (hematoporphyrin, 5-aminolevulinic acid, chlorin derivatives, etc.) in experimental oncology.
D. A. Tzerkovsky +2 more
doaj +1 more source
Regulatory Mechanisms in Biosystems, 2018 We carried out the clinical validation of pathogenetically substantiated protocols for the treatment of female dogs with tumour lesions of the mammary gland.
D. D. Bely +5 more
doaj +1 more source
Protein Kinase C beta in the tumor microenvironment promotes mammary tumorigenesis
Frontiers in Oncology, 2014 Protein kinase C beta (PKCβ) expression in breast cancer is associated with a more aggressive tumor phenotype, yet the mechanism for how PKCβ is pro-tumorigenic in this disease is still unclear.
Julie A Wallace +11 more
doaj +1 more source
Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation [PDF]
, 2007 Transgenic (TG) mice expressing human chorionic gonadotropin (hCG) beta-subunit under the ubiquitin C promoter, presenting with a moderately elevated level of LH/hCG bioactivity develop multiple neoplasms secondary to the endocrine abnormalities ...
Poutanen, Matti +7 more
core +1 more source