Results 21 to 30 of about 61,960 (179)
Merlin deficiency alters the redox management program in breast cancer
Molecular Oncology, 2021 The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues.
Mateus Mota +6 more
doaj +1 more source
Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype. [PDF]
PLoS ONE, 2014 Mammary epithelial (ME) cells cultured under conventional conditions senesce after several passages. Here, we demonstrate that mouse ME cells isolated from normal mammary glands or from mouse mammary tumor virus (MMTV)-Neu-induced mammary tumors, can be ...
Francisco R Saenz +10 more
doaj +1 more source
Conversion of Mouse Mammary Tumor Virus to a Lymphomagenic Virus [PDF]
Journal of Virology, 2005 ABSTRACT Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of ...
Sanchita, Bhadra +2 more
openaire +2 more sources
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. [PDF]
PLoS ONE, 2012 We have generated a new and improved transgenic mouse strain that permits a temporally controlled expression of transgenes throughout mammary gland development.
Kazuhito Sakamoto +2 more
doaj +1 more source
Bio-Protocol, 2021 Flow cytometry is a popular laser-based technology that allows the phenotypic and functional characterization of individual cells in a high-throughput manner.
Ana Almeida, Miriam Fein, Mikala Egeblad
doaj +1 more source
Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar
Infectious Agents and Cancer, 2017 Background Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors.
Thar Htet San +9 more
doaj +1 more source
Rapid spread of mouse mammary tumor virus in cultured human breast cells
Retrovirology, 2007 Background The role of mouse mammary tumor virus (MMTV) as a causative agent in human breast carcinogenesis has recently been the subject of renewed interest.
Günzburg Walter H +4 more
doaj +1 more source
Effect of trypsin on mouse mammary tumor virus [PDF]
Journal of Virology, 1976 Undisrupted mouse mammary tumor virus (MuMTV) derived from the milk of of RIII mice has been analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electron microscopy after treatment with insolubilized trypsin. No alterations were found in viral fine structure by either freeze-etch or negative-stain electron microscopy.
Sheffield, J B +3 more
openaire +2 more sources
Apc mutation enhances PyMT-induced mammary tumorigenesis.
PLoS ONE, 2011 The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation ...
Jenifer R Prosperi +3 more
doaj +1 more source