Results 11 to 20 of about 61,960 (179)

Decitabine suppresses tumor growth by activating mouse mammary tumor virus and interferon-β pathways [PDF]

Biomolecules & Biomedicine
Decitabine (DAC), a DNA methyltransferase inhibitor (DNMTi), is clinically effective in hematological malignancies such as myelodysplastic syndrome and acute myeloid leukemia, but its precise antineoplastic mechanisms remain incompletely understood ...
Ryan Johnson, Andrew Brola, Cade Wycoff, William Wycoff, Seth Neumeyer, Richard Tuttle, Sarah Light, Jiayi Li, Stephen Christensen, Yingguang Liu   +9 more
doaj   +2 more sources

Pericentriolar Targeting of the Mouse Mammary Tumor Virus GAG Protein. [PDF]

PLoS ONE, 2015
The Gag protein of the mouse mammary tumor virus (MMTV) is the chief determinant of subcellular targeting. Electron microscopy studies show that MMTV Gag forms capsids within the cytoplasm and assembles as immature particles with MMTV RNA and the Y box ...
Guangzhi Zhang, David Sharon, Juan Jovel, Lei Liu, Eytan Wine, Nasser Tahbaz, Stanislav Indik, Andrew Mason   +7 more
doaj   +2 more sources

Prevalence of Mouse Mammary Tumor Virus (MMTV)-like sequences in human breast cancer tissues and adjacent normal breast tissues in Saudi Arabia [PDF]

BMC Cancer, 2018
Background Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality. Sequences similar to Mouse Mammary Tumor Virus (MMTV) were detected in human breast cancer in several studies from different ...
Reem Al Dossary, Khaled R. Alkharsah, Haitham Kussaibi   +2 more
doaj   +2 more sources

Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect [PDF]

BMC Biology
Background Tumor-associated architecture and emerging mechanical properties (forces, pressure, tension, stiffness) affect the growth and invasiveness of cancer cells.
Lisbeth Berrueta, Chandra Bhan, Yi He, Rebecca D. Thompson, Oscar Safairad, Andrew D. Doyle, Paola Pérez, Daniel Martin, Mazen Mezher, Alexander Cartagena-Rivera, Gary J. Badger, Helene M. Langevin   +11 more
doaj   +2 more sources

Involvement of APOBEC3A/B Deletion in Mouse Mammary Tumor Virus (MMTV)-like Positive Human Breast Cancer [PDF]

Diagnostics, 2023
Nathalia De Sousa PEREIRA, Marla Karine Amarante, Glauco A F Vitiello   +2 more
exaly   +2 more sources

A Viral Protein Antagonist for Both AID and APOBEC3 [PDF]

Viruses
The APOBEC family of cytidine deaminases is part of the innate immune response to infections by multiple RNA- and DNA-containing viruses. Since the activity of these enzymes, typically APOBEC3, often involves mutations that inhibit or block viral ...
Jaquelin P. Dudley
doaj   +2 more sources

Characterization of Mammary Tumors Arising from MMTV-PyVT Transgenic Mice

Current Issues in Molecular Biology, 2023
Among genetically engineered mouse models of breast cancer, MMTV-PyVT is a mouse strain in which the oncogenic polyoma virus middle T antigen is driven by the mouse mammary tumor virus promoter. The aim of the present study was to perform morphologic and
Chien-Liang Liu, Wen-Chien Huang, Shih-Ping Cheng, Ming-Jen Chen, Chi-Hsin Lin, Shao-Chiang Chang, Yuan-Ching Chang   +6 more
doaj   +1 more source

Lessons Learned from Mouse Mammary Tumor Virus in Animal Models [PDF]

ILAR Journal, 2016
Jaquelin Dudley, Tatyana Golovkina, Susan R Ross   +2 more
exaly   +2 more sources

Special Issue “Human Betaretrovirus and Related Diseases”

Viruses, 2022
A betaretrovirus resembling mouse mammary tumor virus (MMTV) was first linked with human breast cancer over 50 years ago [...]
Andrew L. Mason
doaj   +1 more source

Cryoelectron Microscopy of Mouse Mammary Tumor Virus [PDF]

Journal of Virology, 2004
ABSTRACT Cryoelectron microscopy of Mouse mammary tumor virus , a Betaretrovirus , provided information about glycoprotein structure and core formation. The virions showed the broad range of diameters typical of retroviruses.
Briggs, J., Watson, B., Gowen, B., Fuller, S.   +3 more
openaire   +3 more sources