Results 31 to 40 of about 63,529 (225)
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages [PDF]
, 2007 Genetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy.
Pollard, Jeffrey W +7 more
core +1 more source
Discovery of novel MKL1 target genes important for cancer progression and metastasis : a focus on WNT1 inducible signaling pathway protein 1 (WISP1/CCN4) [PDF]
, 2015 Tenascin-C (TNC) is involved in tumor initiation and metastasis, and high TNC expression has been associated with poor prognosis in cancers such as glioma, breast, colon and lung carcinoma (Orend and Chiquet-Ehrismann, 2006; Oskarsson, 2013).
Gürbüz, Irem
core +1 more source
Targeting tumor vasculature [PDF]
, 2009 Targeting tumor vasculature is the common theme for the three separate studies presented in this thesis. The studies comprise the roles of components of three signaling pathways (networks) in several steps of blood vessel formation, and related tumor ...
Samaržija, Ivana
core +1 more source
Breast Cancer: Basic and Clinical Research, 2020 Background: Viral cause of sporadic breast cancer (SBC) has been suggested based on the experimental murine model of mammary tumor caused by mouse mammary tumor virus (MMTV), Epstein-Barr virus (EBV), and human papillomavirus (HPV).
Mohammad Al Hamad +9 more
doaj +1 more source
Infectious Agents and Cancer, 2017 Background Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast cancer. Here we demonstrate that these
James S. Lawson, Wendy K. Glenn
doaj +1 more source
A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. [PDF]
PLoS ONE, 2017 This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder
Maria M Szwarc +5 more
doaj +1 more source
Amplification of mouse mammary tumor virus genomes in non-mammary tumor cells [PDF]
Journal of Virology, 1989 Extra proviral copies of mouse mammary tumor virus (MMTV) are known to be present in the genomes of certain T-cell lymphomas of mice. Analysis of additional non-mammary tumor cell types known to express MMTV transcripts and antigens revealed the presence of extra acquired MMTV proviruses in a pituitary tumor cell line, a macrophage line, and Leydig ...
J, Racevskis, H, Beyer
openaire +2 more sources
A Transgenic MMTV-Flippase Mouse Line for Molecular Engineering in Mammary Gland and Breast Cancer Mouse Models. [PDF]
, 2019 Genetically engineered mouse models have become an indispensable tool for breast cancer research. Combination of multiple site-specific recombination systems such as Cre/loxP and Flippase (Flp)/Frt allows for engineering of sophisticated, multi-layered ...
Christofori, Gerhard +5 more
core +1 more source
Molecular Imaging, 2007 Vascular endothelial growth factor (VEGF) is a major inducer of angiogenesis. We generated a transgenic reporter mouse, VEGF-GL, in which an enhanced green fluorescent protein-luciferase fusion protein is expressed under the control of a human VEGF-A ...
Shannon L. Faley +7 more
doaj +1 more source