Results 31 to 40 of about 88,076 (273)
Apc mutation enhances PyMT-induced mammary tumorigenesis.
PLoS ONE, 2011 The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation ...
Jenifer R Prosperi +3 more
doaj +1 more source
Discovery of novel MKL1 target genes important for cancer progression and metastasis : a focus on WNT1 inducible signaling pathway protein 1 (WISP1/CCN4) [PDF]
, 2015 Tenascin-C (TNC) is involved in tumor initiation and metastasis, and high TNC expression has been associated with poor prognosis in cancers such as glioma, breast, colon and lung carcinoma (Orend and Chiquet-Ehrismann, 2006; Oskarsson, 2013).
Gürbüz, Irem
core +1 more source
Targeting tumor vasculature [PDF]
, 2009 Targeting tumor vasculature is the common theme for the three separate studies presented in this thesis. The studies comprise the roles of components of three signaling pathways (networks) in several steps of blood vessel formation, and related tumor ...
Samaržija, Ivana
core +1 more source
Cells, 2013 Tumorigenesis is often described as a result of accumulated mutations that lead to growth advantage and clonal expansion of mutated cells. There is evidence in the literature that cancer cells are influenced by the microenvironment.
Sonia M. Rosenfield, Gilbert H. Smith
doaj +1 more source
Intestinal Immune System and Amplification of Mouse Mammary Tumor Virus
Frontiers in Cellular and Infection Microbiology, 2022 Mouse mammary tumor virus (MMTV) is a virus that induces breast cancer in mice. During lactation, MMTV can transmit from mother to offspring through milk, and Peyer’s patches (PPs) in mouse intestine are the first and specific target organ.
Lankai Chen +6 more
doaj +1 more source
Human saliva as route of inter-human infection for mouse mammary tumor virus
OncoTarget, 2015 Etiology of human breast cancer is unknown, whereas the Mouse Mammary Tumor Virus (MMTV) is recognized as the etiologic agent of mouse mammary carcinoma.
C. Mazzanti +15 more
semanticscholar +1 more source
In Vitro Production of Mouse Mammary Tumor Virus in a Mouse Mammary Tumor Ascites Line [PDF]
Proceedings of the National Academy of Sciences, 1973 An ascites line derived from a spontaneous mouse mammary carcinoma produces, on explantation and cultivation in vitro , large amounts of oncornavirus particles. The biochemical, biophysical, and electron microscopic characteristics of the virions are described.
Keydar, J +3 more
openaire +2 more sources
Molecular Cancer, 2013 The canonical milk-transmitted mouse mammary tumor virus (MMTV) of C3H mice (C3H-MMTV) rapidly induces tumors in 90% of infected animals by 8 months of age.
Robert D. Bruno +2 more
semanticscholar +1 more source
Infectious Agents and Cancer, 2017 Background Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast cancer. Here we demonstrate that these
James S. Lawson, Wendy K. Glenn
doaj +1 more source
A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. [PDF]
PLoS ONE, 2017 This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder
Maria M Szwarc +5 more
doaj +1 more source