Results 51 to 60 of about 88,076 (273)

Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

Cell Reports, 2021
Summary: Basal breast cancer is associated with younger age, early relapse, and a high mortality rate. Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate the cellular basis of tumor progression during the specification ...
Fátima Valdés-Mora, Robert Salomon, Brian Stewart Gloss, Andrew Man Kit Law, Jeron Venhuizen, Lesley Castillo, Kendelle Joan Murphy, Astrid Magenau, Michael Papanicolaou, Laura Rodriguez de la Fuente, Daniel Lee Roden, Yolanda Colino-Sanguino, Zoya Kikhtyak, Nona Farbehi, James Ronald William Conway, Neblina Sikta, Samantha Richelle Oakes, Thomas Robert Cox, Seán Ignatius O’Donoghue, Paul Timpson, Christopher John Ormandy, David Gallego-Ortega   +21 more
doaj   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Expression of Mouse Mammary Tumor Virus Envelope Protein Does Not Prevent Superinfection In Vivo or In Vitro

, 1999
Inbred mice expressing endogenous mouse mammary tumor virus envelope proteins can be infected with exogenous virus, and the mammary tumors that develop in these mice usually have many proviruses integrated in their genomes, indicating that this virus is ...
Denis Kapkov, Tatyana V. Golovkina, Ross, S R, Dzuris, John L., Wei Zhu, Kapkov, Denis, Susan R. Ross, Zhu, Wei, Golovkina, Tatyana V., John L. Dzuris, Dzuris, J L, Golovkina, T V, Kapkov, D, Ross, Susan R., Zhu, W   +14 more
core   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation

FEBS Open Bio, 2018
Mammalian eukaryotic translation initiation factor 3 (eIF3) is the largest complex of the translation initiation factors. The eIF3 complex is comprised of thirteen subunits, which are named eIF3a to eIF3 m in most multicellular organisms.
Daichi Sadato, Tomio Ono, Saki Gotoh‐Saito, Naoki Kajiwara, Namiko Nomura, Masako Ukaji, Liying Yang, Kenji Sakimura, Youichi Tajima, Keisuke Oboki, Futoshi Shibasaki   +10 more
doaj   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Loss of STAT1 from Mouse Mammary Epithelium Results in an Increased Neu-Induced Tumor Burden

Neoplasia: An International Journal for Oncology Research, 2010
Type I and type II classes of interferons (IFNs) signal through the JAK/STAT1 pathway and are known to be important in adaptive and innate immune responses and in protection against tumors.
Peter J. Klover, William J. Muller, Gertraud W. Robinson, Ruth M. Pfeiffer, Daisuke Yamaji, Lothar Hennighausen   +5 more
doaj   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression

, 2008
Matrix metalloproteinase (MMP) 13 (collagenase 3) is an extracellular matrix remodeling enzyme that is induced in myofibroblasts during the earliest invasive stages of human breast carcinoma, suggesting that it is involved in tumor progression.
Lund, Leif R, Zena Werb, Dylan R Edwards, Askautrud, Hanne A, Lund, Leif R., Mikala Egeblad, Pedersen, T. X., Edwards, D. R., Leif R Lund, Rank, Fritz, Ib J Christensen, Pedersen, Tanja X., Fritz Rank, Nielsen, Boye S., Christensen, Ib J, Askautrud, Hanne A., Lund, L. R., Edwards, Dylan R., Tanja X Pedersen, Boye S Nielsen, Werb, Zena, Egeblad, M., Christensen, I. J., Caroline J Pennington, Hanne A Askautrud, Rank, F., Edwards, Dylan R, Werb, Z., Askautrud, H. A., Nielsen, Boye S, Pennington, C. J., Egeblad, Mikala, Christensen, Ib J., Pennington, Caroline J, Pennington, Caroline J., Nielsen, B. S., Pedersen, Tanja X   +36 more
core   +1 more source

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors

OncoTarget, 2012
The accumulation of mutations is a contributing factor in the initiation of premalignant mammary lesions and their progression to malignancy and metastasis.
R. Callahan, U. Mudunuri, S. Bargo, A. Raafat, David McCurdy, Corinne A Boulanger, William J. Lowther, R. Stephens, B. Luke, C. Stewart, Xiaolin Wu, D. Munroe, Gilbert H. Smith   +12 more
semanticscholar   +1 more source